Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity.
Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity.
复制标题
从下呼吸道清除副百日咳博德特氏菌需要体液和细胞免疫。
DOI：
10.1128/iai.73.10.6508-6513.2005
复制
发表时间：
2005
影响因子：
3.1
通讯作者：
Harvill,EricT
中科院分区：
文献类型：
--
作者：
Wolfe,DanielN;Kirimanjeswara,GirishS;Harvill,EricT
副百日咳博德特氏菌和百日咳博德特氏菌是引起百日咳（一种急性免疫性疾病）密切相关的物种。它们同时在同一宿主群体中共存，疫苗研究表明 B.百日咳疫苗对B的影响不大。副百日咳感染或疾病表明，每种引起的保护性免疫不能有效地交叉保护免受另一种的影响。尽管保护性免疫机制是B.百日咳已得到充分研究，B.副百日咳没有。本研究探讨了 B.副百日咳通过记忆免疫从下呼吸道清除。血清抗体对于消除这种细菌是必要且充分的，并且血清抗体介导的清除需要CD4+T细胞、补体和中性粒细胞。缺乏免疫球蛋白A的小鼠控制或清除感染的能力没有缺陷。有趣的是，血清抗体介导的 B 清除。副百日咳不需要抗体介导的 B 清除所需的 Fc 受体。百日咳。这些数据共同支持了对 B 的保护性免疫机制的模型。副百日咳与 B 相似但不同。百日咳。
Bordetella parapertussisandBordetella pertussisare closely related species that cause whooping cough, an acute, immunizing disease. Their coexistence in the same host populations at the same time and vaccine studies showing thatB. pertussisvaccines have little effect onB. parapertussisinfection or disease suggest that the protective immunity induced by each does not efficiently cross protect against the other. Although the mechanisms of protective immunity toB. pertussishave been well studied, those ofB. parapertussishave not. The present study explores the mechanism by whichB. parapertussisis cleared from the lower respiratory tract by anamnestic immunity. Serum antibodies are necessary and sufficient for elimination of this bacterium, and CD4+T cells, complement, and neutrophils are required for serum antibody-mediated clearance. Mice lacking immunoglobulin A had no defect in their ability to control or clear infection. Interestingly, serum antibody-mediated clearance ofB. parapertussisdid not require Fc receptors that are required for antibody-mediated clearance ofB. pertussis. Together these data support a model for the mechanism of protective immunity toB. parapertussisthat is similar but distinct from that ofB. pertussis.