Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk.
Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk.
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DOI：
10.1002/mds.26573
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Chen H
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文献类型：
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作者：
Shrestha S;Lutsey PL;Alonso A;Huang X;Mosley TH Jr;Chen H
低维生素D水平在帕金森病（PD）患者中很常见。实验证据进一步表明，维生素D可能对PD有保护作用。我们前瞻性地评估了12,762名动脉粥样硬化风险社区研究队列参与者血清25-羟基维生素D与PD之间的关系。于1990-1992年收集血清样本，并采用液相色谱-质谱法测定25-羟基维生素D。截至2008年12月31日，共确定了67例PD事件。中位随访时间为17年。我们使用考克斯比例风险模型来获得风险比和95%置信区间，并对年龄、性别和种族进行了调整。我们没有发现血清25-羟基维生素D浓度与PD风险之间存在任何相关性，无论血清25-羟基维生素D是如何建模的。与血清25-羟基维生素D < 20 ng/mL的受试者相比，20-30 ng/mL的PD风险比为1.05（95%置信区间= 0.58，1.90），≥ 30 ng/mL的PD风险比为1.14（95%置信区间= 0.59，2.23）。在敏感性分析中获得了类似的结果，其中仅包括白色受试者，并按随访时间分层。这项前瞻性研究没有支持维生素D可以降低PD风险的假设。
Low vitamin D levels are common among patients with Parkinson’s disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. We prospectively assessed the association between serum 25-hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort. Serum samples were collected in 1990–1992 and 25-hydroxyvitamin D was measured by liquid chromatography mass spectrometry. A total of 67 incident PD cases were identified through December 31, 2008. The median length of follow-up was 17 years. We used Cox proportional hazards models to obtain hazard ratios and 95% confidence intervals, adjusting for age, sex, and race. We did not find any association between serum 25-hydroxyvitamin D concentrations and PD risk, regardless of how serum 25-hydroxyvitamin D was modeled. Compared to participants with serum 25-hydroxyvitamin D < 20 ng/mL, the hazards ratio for PD was 1.05 (95% confidence interval = 0.58, 1.90) for 20–30 ng/mL and 1.14 (95% confidence interval = 0.59, 2.23) for ≥ 30 ng/mL. Similar results were obtained in sensitivity analyses that included white participants only and that were stratified by the length of follow-up. This prospective study lends no support to the hypothesis that vitamin D may reduce the risk of PD.