Photo-Mediated Decarboxylative Ketonization of Atropic Acids with Sulfonyl Hydrazides: Direct Access to β-Ketosulfones
Photo-Mediated Decarboxylative Ketonization of Atropic Acids with Sulfonyl Hydrazides: Direct Access to β-Ketosulfones
复制标题
光介导的阿托酸与磺酰肼的脱羧酮化：直接获得 β-酮砜
DOI：
10.1002/adsc.201901525
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发表时间：
2020-01-30
影响因子：
5.4
通讯作者：
He, Yan-Hong
中科院分区：
文献类型：
--
作者：
Chen, Jie;Allyson, Zoe G.;He, Yan-Hong
公开了通过阿托酸的光介导脱羧酮化有效形成合成和生物学相关的β-酮砜。该方法具有无金属条件、良好的官能团相容性、易于获得的起始材料以及使用普遍存在的分子氧作为氧源和氧化剂的特点。此外，机理研究表明，脱羧酮化反应通过自由基机制进行，并可能涉及自由基链式反应。
An efficient formation of synthetically and biologically relevant beta-ketosulfones via a photo-mediated decarboxylative ketonization of atropic acids was disclosed. The approach features metal-free conditions, good functional group compatibility, readily available starting materials and the use of ubiquitous dioxygen as both oxygen source and oxidant. Furthermore, mechanistic studies reveal that the decarboxylative ketonization reaction proceeds via a radical mechanism and may involve a radical chain reaction.