Involvement of the caudal striatum in auditory processing: c-fos response to cortical application of picrotoxin and to auditory stimulation
Involvement of the caudal striatum in auditory processing: c-fos response to cortical application of picrotoxin and to auditory stimulation
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DOI：
10.1016/0169-328x(96)00063-0
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发表时间：
1996-09-05
期刊：
影响因子：
--
通讯作者：
DemotesMainard, J
中科院分区：
文献类型：
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作者：
Arnauld, E;Jeantet, Y;DemotesMainard, J
皮质纹状体连接的地形组织被假定为遵循纵向模式，每个皮质区域投射在一个纵向条带上，该条带沿着纹状体的整个头尾轴伸展。然而，与头侧纹状体区相比，尾侧纹状体在连接性和神经元表型方面表现出不同的特征。通过皮层激活或感觉刺激诱导纹状体c-fos表达可能会使这些功能性皮质-纹状体关系更加明朗。在本研究中，我们研究了局部应用印防己毒素对小鼠纹状体Fos免疫反应性（Fos-IR）的皮质激活的影响，特别是纹状体的尾部。听觉皮层的激活诱导了仅限于尾侧纹状体的同侧致密Fos-IR，即，在尾内侧纹状体和纹状体底部的尾部，和一个非常稀疏的标记在内侧区域的吻侧纹状体。相反，感觉运动和视觉皮质的激活只导致Fos IR在纹状体的主要吻侧部分，没有反应在纹状体的尾端。另一方面，视觉或听觉刺激在清醒的动物未能诱导c-fos在纹状体的表达。然而，使用c-fos mRNA的定量原位杂交，我们发现听觉刺激而不是视觉刺激显着增强了对D1激动剂SKF 38393（2 mg/kg，腹腔注射）的c-fos反应在纹状体的尾部这些功能的观察表明，尽管更广泛的皮质-纹状体连接模式推导出跟踪实验，从听觉系统的最强功能的预测主要集中到一个有限的部分尾侧纹状体，根据连接模式，这是令人想起的横向分割提出的早期病变研究皮质纹状体的预测。
The topographical organization of corticostriatal connections have been postulated to follow a longitudinal pattern, each cortical area projecting on a longitudinal strip stretching along the whole rostro-caudal axis of the striatum. However, compared to the rostral striatal region, the caudal striatum exhibits distinct features in terms of connectivity and neuronal phenotype. The induction of c-fos expression in the striatum by cortical activation or sensory stimulation may throw more light on these functional corticostriatal relationships. In the present study, we examined the effects of cortical activation by local application of picrotoxin on the Fos-immunoreactivity (Fos-IR) in the striatum of the mouse, with special reference to the caudal part of the striatum. Activation of the auditory cortex induced a dense ipsilateral Fos-IR restricted to the caudal striatum, i.e., in the caudo-medial striatum and in the caudal part of fundus striati, and a very sparse labelling in the medial region of the rostral striatum. Conversely, activation of both sensori-motor and visual cortices only resulted in Fos-IR in the main rostral part of the striatum, without response in the caudal extremity of the striatum. On the other hand, visual or auditory stimulation in awake animals failed to induce c-fos expression in the striatum. However, using quantitative in-situ hybridization for c-fos mRNA, we found that auditory, but not visual stimulation significantly potentiated the c-fos response to the D1 agonist SKF 38393 (2 mg/kg, i.p.) in the caudal part of the striatum. These functional observations suggest that, despite a more widespread cortico-striatal connection pattern deduced from tracing experiments, the strongest functional projections from the auditory system mainly converge onto a restricted part of the caudal striatum, according to a connection pattern that is reminiscent of the transverse segmentation proposed in early lesioning studies of corticostriatal projections.