Innovations in biological assessments of chronic stress through hair and nail cortisol: Conceptual, developmental, and methodological issues
Innovations in biological assessments of chronic stress through hair and nail cortisol: Conceptual, developmental, and methodological issues
复制标题
DOI：
10.1002/dev.21830
复制
发表时间：
2019-04-01
影响因子：
2.2
通讯作者：
Doan, Stacey N.
中科院分区：
文献类型：
--
作者：
Liu, Cindy H.;Doan, Stacey N.
现有的关于压力体验背后的生物机制的研究大多集中在当下的压力上，而不是长期压力上，后者可以说是对长期结果更有力的预测。最近的方法创新为慢性压力的新研究开辟了道路，对发展研究人员和那些研究健康和逆境的人有很好的启示。特别是，越来越多的研究将重点放在慢性压力评估上，依靠来自头发和指甲的皮质醇作为慢性压力的生物标志物。在本文中，我们概述了它们的使用，描述了毛发和指甲皮质醇在整个生命周期中应该如何不同地概念化，发育因素如何影响其解释，以及在何种情况下其使用可能在方法上更合理。本综述的目的是引发进一步的讨论，并鼓励仔细的研究设计，利用头发和指甲皮质醇来了解早期发育时期慢性应激暴露的影响，在不利的环境中，以及与心理和身体健康结果的关联。
Much of the existing research on biological mechanisms underlying the stress experience has focused largely on moment-to-moment stress, rather than on chronic stress, an arguably more powerful predictor of long-term outcomes. Recent methodological innovations have paved the way for new lines of research on chronic stress, with promising implications for developmental researchers and for those who study health and adversity. In particular, there are increasing studies that have focused on chronic stress assessments by relying on cortisol derived from hair and nails as a biomarker for chronic stress. In this paper, we provide an overview of their use, describe how hair and nail cortisol ought to be conceptualized differently across the lifespan, how developmental factors may impact its interpretation, and the circumstances under which its use may be more methodologically sensible. The purpose of this review is to provoke further discussion and encourage careful research designs that utilize hair and nail cortisol for understanding the effects of chronic stress exposure from the early developmental period, across adverse contexts, and in association with psychological and physical health outcomes.