Astrocytic vesicle mobility in health and disease.
Astrocytic vesicle mobility in health and disease.
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DOI：
10.3390/ijms140611238
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发表时间：
2013-05-27
影响因子：
5.6
通讯作者：
Zorec R
中科院分区：
文献类型：
--
作者：
Potokar M;Vardjan N;Stenovec M;Gabrijel M;Trkov S;Jorgačevski J;Kreft M;Zorec R
星形胶质细胞不再被认为是神经元的附属，相反，现在被认为在大脑信号传导中起着积极的作用。星形胶质细胞与神经元和其他非神经元细胞之间的细胞间通讯涉及通过胞外和胞吞过程通过细胞内囊泡的运输进行分子交换。最近对星形胶质细胞中单个囊泡运动的研究促使人们对星形胶质细胞如何参与神经组织的信息加工有了新的认识。在这里，我们回顾了几种类型的膜结合囊泡的运输，这些囊泡专门参与(i)胶质递质（谷氨酸，腺苷5 ' -三磷酸，房利钠肽）的细胞间通讯，（ii）转运体和受体的质膜交换（EAAT2, MHC-II），以及（iii）携带水通道蛋白的囊泡移动（AQP4）参与水稳态过程。在生理和病理条件下，如肌萎缩侧索硬化症、多发性硬化症，以及星形胶质细胞导致神经炎症的状态下，星形胶质细胞中囊泡运输的特性与邻近细胞的网络进行了讨论。
Astrocytes are no longer considered subservient to neurons, and are, instead, now understood to play an active role in brain signaling. The intercellular communication of astrocytes with neurons and other non-neuronal cells involves the exchange of molecules by exocytotic and endocytotic processes through the trafficking of intracellular vesicles. Recent studies of single vesicle mobility in astrocytes have prompted new views of how astrocytes contribute to information processing in nervous tissue. Here, we review the trafficking of several types of membrane-bound vesicles that are specifically involved in the processes of (i) intercellular communication by gliotransmitters (glutamate, adenosine 5′-triphosphate, atrial natriuretic peptide), (ii) plasma membrane exchange of transporters and receptors (EAAT2, MHC-II), and (iii) the involvement of vesicle mobility carrying aquaporins (AQP4) in water homeostasis. The properties of vesicle traffic in astrocytes are discussed in respect to networking with neighboring cells in physiologic and pathologic conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, and states in which astrocytes contribute to neuroinflammatory conditions.
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影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
影响因子：
4.8
作者：
Coco, S;Calegari, F;Verderio, C
通讯作者：
Verderio, C
影响因子：
4.8
作者：
Calegari, F;Coco, S;Rosa, P
通讯作者：
Rosa, P
影响因子：
8
作者：
Almqvist, Jonas;Huang, Yafei;Hovmoeller, Sven
通讯作者：
Hovmoeller, Sven
影响因子：
4.8
作者：
Arima, H;Yamamoto, N;Asai, K
通讯作者：
Asai, K