CSF -: Neurofilament correlates with outcome after aneurysmal subarachnoid hemorrhage
CSF -: Neurofilament correlates with outcome after aneurysmal subarachnoid hemorrhage
复制标题
DOI：
10.1016/j.neulet.2006.05.029
复制
发表时间：
2006-08-14
影响因子：
2.5
通讯作者：
Rosengren, L.
中科院分区：
文献类型：
--
作者：
Nylen, K.;Csajbok, L. Z.;Rosengren, L.
动脉瘤性蛛网膜下腔出血（aSAH）是一种毁灭性事件。出血后，许多病理生理变化和临床因素决定结果。毫不奇怪，基于单一因素预测结果的尝试都失败了。入院时的神经系统状态分级和 CT 上的血液分布是最强的预测因素。有证据表明，脑脊液（CSF）蛋白可以作为脑损伤程度的标志物。本研究的重点是神经丝蛋白 (NFL) 的轻单位，此前未在 aSAH 中进行评估。在出血后 10-14 天连续对 48 名 aSAH 患者进行了腰椎穿刺 (LP)、根据世界神经外科医生联合会 (WFNS) 进行的神经学分级以及根据美国国立卫生研究院卒中量表 (NIHSS) 进行的神经学检查。使用 ELISA 分析 CSF-NFL 浓度。一年后对结果进行评估，并根据扩展格拉斯哥结果量表（GOSE）进行分类。在一年后的随访中发现 CSF-NFL 和 GOSE 之间存在显着相关性。 CSF-NFL 还与腰椎穿刺当天的 WFNS 和 NIHSS 相关。 CSF-NFL 是脑损伤的生化标志物，与动脉瘤性蛛网膜下腔出血后的神经状态和长期结果相关。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating event. Following the bleeding, a number of pathophysiological changes and clinical factors determine outcome. Not surprisingly, attempts to predict outcome based on a single factor have failed. The neurological status graded at admission to hospital and distributions of the blood on CT are the strongest predictors. There is evidence that cerebrospinal fluid (CSF) proteins may serve as markers of the extent of brain damage. The present study is focused on the light unit of neurofilament protein (NFL), previously not evaluated in aSAH. Lumbar puncture (LP), neurological grading according to World Federation of Neurological Surgeons (WFNS) and neurological examination according to the National Institute of Health Stroke Scale (NIHSS) were performed in 48 consecutive patients with aSAH 10-14 days after the hemorrhage. CSF-NFL concentrations were analyzed using an ELISA. Outcome was assessed after I year and categorised according to the extended Glasgow Outcome Scale (GOSE). A significant correlation between CSF-NFL and GOSE was detected at follow up after I year. CSF-NFL also correlated with WFNS and NIHSS on the day of the lumbar puncture. CSF-NFL is a biochemical marker of brain damage correlating to neurological status and long-term outcome after aneurysmal subarachnoid hemorrhage. (c) 2006 Elsevier Ireland Ltd. All rights reserved.