Determining Agreement Between Preoperative Computed Tomography Lymphography and Near Infrared Fluorescence Intraoperative Imaging for Sentinel Lymph Node Mapping in Dogs with Oral Tumors.
Determining Agreement Between Preoperative Computed Tomography Lymphography and Near Infrared Fluorescence Intraoperative Imaging for Sentinel Lymph Node Mapping in Dogs with Oral Tumors.
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确定术前计算机断层扫描淋巴管造影和近红外荧光术中成像之间的一致性，用于口腔肿瘤犬的前哨淋巴结定位。
DOI：
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发表时间：
2021
影响因子：
2.1
通讯作者：
S. Nykamp
中科院分区：
文献类型：
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作者：
Jennifer Wan;M. Oblak;A. Ram;Ameet Singh;S. Nykamp
头部和颈部的淋巴引流是可变的，具有显著的交叉，因此前哨淋巴结（SLN）映射可以帮助确保采样适当的淋巴结。为了提高灵敏度，建议采用多种方式进行SLN标测，并结合术前计算机断层扫描淋巴造影（CTL）和术中近红外荧光成像（NIRF），使用吲哚菁绿色（ICG）+/-亚甲蓝（MB）染料。本研究的目的是描述一种术中ICG淋巴造影的方法，并确定在患有口腔肿瘤的犬中使用术前CTL和术中ICG NIRF + MB淋巴造影（IOL）检测SLN的一致性。其中包括14只客户拥有的狗。所有犬均使用碘化造影剂进行术前CTL，并使用外窥镜进行术中IOL。CTL增强、蓝染或荧光的淋巴结被认为是前哨淋巴结。当CTL和IOL联合使用时，SLN的总体识别率为100%。共识别出57个SLN。吲哚菁绿色NIRF鉴定的SLN比例（91%; 52/57）高于MB（50.8%; 29/57）和CTL（42.1%; 24/57）。使用Fleiss kappa，所有三种模式识别出18个SLN，具有相当的一致性。这些研究结果表明，术前CTL与术中SLN映射技术相结合，可以大大提高准确检测口腔肿瘤犬SLN的能力。本文受版权保护。All rights reserved.
Lymphatic drainage from the head and neck is variable with significant crossover, therefore sentinel lymph node (SLN) mapping can help ensure the appropriate lymph nodes are sampled. To improve sensitivity, SLN mapping utilizing multiple modalities and a combination of preoperative computed tomography lymphography (CTL) and intraoperative near infrared fluorescence imaging (NIRF) with indocyanine green (ICG) +/- methylene blue (MB) dye has been suggested. The aim of this study was to describe a method for intraoperative ICG lymphography and determine agreement for SLN detection using preoperative CTL and intraoperative ICG NIRF + MB lymphography (IOL) in dogs with oral tumors. Fourteen client-owned dogs were included. All dogs had preoperative CTL with iodinated contrast and intraoperative IOL with an exoscope. Lymph nodes with CTL contrast-enhancement, blue staining or fluorescence were considered sentinel. The overall SLN identification rate was 100% when CTL and IOL were combined. A total of 57 SLNs were identified. Indocyanine green NIRF identified a greater proportion of SLNs (91%; 52/57) compared to MB (50.8%; 29/57) and CTL (42.1%; 24/57). Eighteen SLNs were identified by all three modalities with a fair level of agreement using Fleiss kappa. These findings suggest a combination of preoperative CTL with intraoperative SLN mapping techniques may greatly improve the ability to accurately detect the SLN in dogs with oral tumours. This article is protected by copyright. All rights reserved.
影响因子：
51.1
作者：
Krag, David N.;Anderson, Stewart J.;Julian, Thomas B.;Brown, Ann M.;Harlow, Seth P.;Costantino, Joseph P.;Ashikaga, Takamaru;Weaver, Donald L.;Mamounas, Eleftherios P.;Jalovec, Lynne M.;Frazier, Thomas G.;Noyes, R. Dirk;Robidoux, Andre;Scarth, Hugh M. C.;Wolmark, Norman
通讯作者：
Wolmark, Norman
DOI：
10.1056/nejmoa1310460
发表时间：
2014-02-13
期刊：
The New England journal of medicine
影响因子：
--
作者：
Morton DL;Thompson JF;Cochran AJ;Mozzillo N;Nieweg OE;Roses DF;Hoekstra HJ;Karakousis CP;Puleo CA;Coventry BJ;Kashani-Sabet M;Smithers BM;Paul E;Kraybill WG;McKinnon JG;Wang HJ;Elashoff R;Faries MB;MSLT Group
通讯作者：
MSLT Group