Differential analysis of donor characteristics for pancreas and islet transplantation
Differential analysis of donor characteristics for pancreas and islet transplantation
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DOI：
10.1016/j.transproceed.2006.08.040
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发表时间：
2006-10-01
影响因子：
0.9
通讯作者：
Frutos, M. A.
中科院分区：
文献类型：
--
作者：
Briones, R. M.;Miranda, J. M.;Frutos, M. A.
选择合适的供体是胰岛分离和移植成功的关键。虽然先前已经确定了几个重要的与捐助者相关的因素，但这些因素需要在我们的环境中得到确认。本研究的目的是：（1）比较胰岛供体和胰腺供体（国家移植登记处）的特征。(2)比较在我们的设施中成功分离的胰岛供体的特征与胰腺供体的特征，和（3）比较在这个设施中的胰岛供体的特征，无论分离是否成功，与其他地方的供体，其胰岛被移植并包括在协作胰岛移植登记中。在我们的设施完成的35个胰岛分离的各种特征进行了分析。我们的胰岛供体和胰腺供体之间的供体年龄、体重指数（BMI）和体重存在显著差异（P <0.001）。这些差异在对应于成功分离的供体与胰腺供体相比的亚组分析中保持（P <0.01）。我们的胰岛分离设施中最成功的分离与BMI> 25的捐赠者有关。在体重> 90 kg的供体中，成功分离（> 300，000 IEq）的百分比较高。我们的结论是，胰腺移植和胰岛移植的供体资料之间几乎没有重叠。更具体的选择标准，相对于BMI和体重的胰岛供体可能会导致更大的成功胰岛分离和移植。
Suitable selection of donors is key to the success of human islet isolation and transplantation. Although several important donor-related factors have been identified previously, they needed to be confirmed in our setting. The aims of this study were: (1) to compare the characteristics of islet donors with those of pancreas donors (national transplant registry). (2) to compare the characteristics of islet donors resulting in a successful isolation in our facility with the characteristics of pancreas donors, and (3) to compare the characteristics of islet donors at this facility, whether or not isolation was successful, with donors elsewhere whose islets were transplanted and included in the Collaborative Islet Transplant Registry. The 35 islet isolations completed at our facility were analyzed for various characteristics. Significant differences were seen in donor age body mass index (BMI), and body weight between our islet donors and our pancreas donors (P < .001). These differences were maintained in the subgroup analysis corresponding to donors of successful isolations compared to pancreas donors (P < .01). Most successful isolations in our islet isolation facility were associated with donors of BMI > 25. The percentage of successful isolation (> 300,000 IEq) was higher among donors with a body weight > 90 kg. We concluded that there was little overlap between the donor profiles for pancreas transplantation and for islet transplantation. More specific selection criteria relative to both BMI and body weight for islet donors may result in greater success of pancreas islet isolation and transplantation.