Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives
Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives
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DOI：
10.1016/j.bbi.2018.09.026
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发表时间：
2019-01-01
影响因子：
15.1
通讯作者：
Vinberg, Maj
中科院分区：
文献类型：
--
作者：
Coello, Klara;Hansen, Tue Haldor;Vinberg, Maj
目的：肠道菌群异常可能与包括精神疾病在内的多种疾病有关。肠道微生物群在双相情感障碍（BD）中几乎没有研究。我们检测了新诊断的BD患者、其未受影响的一级亲属和健康个体的肠道菌群组成。方法：从113名BD患者、39名未受影响的一级亲属和77名健康个体中收集粪便样本，并使用16 S rRNA基因扩增子测序分析肠道菌群。BD患者的肠道微生物群成员与健康个体不同（R-2 = 1.0%，P = 0.008），而未受影响的一级亲属的社区成员则没有。Flavonifractor存在于61%的BD患者，42%的未患病亲属和39%的健康个体中。存在Flavonifractor与BD的比值比为2.9（95%CI：1.6-5.2，P = 5.8 x 10（-4），Q = 0.036）相关。当排除吸烟者时，Flavonifractor的存在与BD的比值比为2.3（95%CI：1.1-5.3，P = 0.019）相关。然而，当仅考虑非吸烟者的子样本时，当在属水平调整所有可能的检测时，BD和Flavonifractor的存在不再相关（Q = 0.6）。BD患者中Flavonifractor的存在与吸烟和女性性别有关，但与年龄、腰围、运动水平、超敏C反应蛋白、当前情感状态、BD亚型、病程或精神药物治疗无关。BD患者中较高的吸烟率促成了我们的研究结果，并且不能排除研究结果受到残余混杂因素的影响。
Objective: An aberrant gut microbiota may be associated with a broad spectrum of diseases including mental illness. The gut microbiota is scarcely studied in bipolar disorder (BD). We examined the gut microbiota composition in patients with newly diagnosed BD, their unaffected first-degree relatives and healthy individuals.Methods: Stool samples were collected from 113 patients with BD, 39 unaffected first-degree relatives and 77 healthy individuals and the microbiota was profiled using 16S rRNA gene amplicon sequencing.Results: The gut microbiota community membership of patients with BD differed from that of healthy individuals (R-2 = 1.0%, P = 0.008), whereas the community membership of unaffected first-degree relatives did not. Flavonifractor was present in 61% of patients with BD, 42% of their unaffected relatives and 39% of healthy individuals. Presence of Flavonifractor was associated with an odds ratio of 2.9 (95%CI: 1.6-5.2, P = 5.8 x 10(-4), Q = 0.036) for having BD. When excluding smokers, presence of Flavonifractor was associated with an odds ratio of 2.3 (95%CI: 1.1-5.3, P = 0.019) for having BD. However, when considering the subsample of non-smokers only, BD and presence of Flavonifractor were no longer associated when adjusted for all possible tests at genus level (Q = 0.6). Presence of Flavonifractor in patients with BD was associated with smoking and female sex, but not with age, waist circumference, exercise level, high-sensitive C-reactive protein, current affective state, subtype of BD, illness duration or psychotropic medication, respectively.Conclusion: Flavonifractor, a bacterial genus that may induce oxidative stress and inflammation in its host, was associated with BD. Higher prevalence of smoking among patients with BD contributed to our findings, and it cannot be excluded that findings are influenced by residual confounding.