Smoking and lung function of lung health study participants after 11 years
Smoking and lung function of lung health study participants after 11 years
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DOI：
10.1164/rccm.2112096
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发表时间：
2002-09-01
影响因子：
24.7
通讯作者：
Murray, RP
中科院分区：
文献类型：
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作者：
Anthonisen, NR;Connett, JE;Murray, RP
肺部健康研究 (LHS) 纳入 11 年后，我们对参加长期随访研究的 77.4% 的幸存参与者进行了肺活量测定。那些没有参加的人往往是年轻的男性重度吸烟者，他们在 LHS 期间继续吸烟。在调整这些因素后，他们的初始 LHS 肺功能与参与者没有差异。最初的 LHS 治疗组（吸烟干预与常规护理）的吸烟习惯趋于一致，但在整个 LHS 期间戒烟的参与者中有 93% 在 11 岁时仍然戒烟。治疗组之间肺功能的差异仍然存在；吸烟干预参与者的 FEV1 下降幅度小于常规护理参与者。在 LHS 开始时戒烟的男性 FEV1 下降率为 30.2 毫升/年，而戒烟的女性则下降 21.5 毫升/年。在这 11 年中，持续吸烟的男性每年减少 66.1 毫升，持续吸烟的女性每年减少 54.2 毫升。当 FEV1 下降以预测正常值的百分比表示时，持续吸烟者中没有明显的性别差异。 11 岁时，38% 的持续吸烟者的 FEV1 低于预测正常值的 60%，而持续戒烟者的这一比例为 10%。
Eleven years after Lung Health Study (LHS) entry, we performed spirometry in 77.4% of surviving participants who enrolled in a long-term follow-up study. Those not enrolling tended to be younger male heavy smokers who continued to smoke during the LHS. Their initial LHS lung function, after adjustment for these factors, did not differ from that of enrollees. Smoking habits by original LHS treatment groups (smoking intervention vs. usual care) tended to converge, but 93% of participants who were abstinent throughout the LHS were still abstinent at 11 years. Differences in lung function between treatment groups persisted; smoking intervention participants had less decline in FEV1 than usual care participants. Men who quit at the beginning of the LHS had an FEV1 rate of decline of 30.2 ml/year, whereas women who quit declined at 21.5 ml/year. Men continuing to smoke throughout the 11 years declined by 66.1 ml/year, and women continuing to smoke declined by 54.2 ml/year. When decline in FEV1 was expressed as a percentage of predicted normal value, no significant sex-based difference was apparent among continuing smokers. At 11 years, 38% of continuing smokers had an FEV1 less than 60% of the predicted norma value compared with 10% of sustained quitters.