Ras promotes cell survival in Drosophila by downregulating hid expression
Ras promotes cell survival in Drosophila by downregulating hid expression
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DOI：
10.1016/s0092-8674(00)81764-x
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发表时间：
1998-10-30
期刊：
影响因子：
64.5
通讯作者：
White, K
中科院分区：
文献类型：
--
作者：
Kurada, P;White, K
在果蝇发育过程中，RAS的激活抑制了细胞的凋亡。遗传证据表明，发育中眼睛中的RAS抗凋亡活性受果蝇EGF受体调节，并通过Raf/MAPK途径发挥作用。该通路活性降低增强了细胞死亡调节因子收割者(RPR)和头部退化缺陷(HID)异位表达所诱导的细胞凋亡，而活性增加则抑制了细胞凋亡。此外，在发育中的胚胎和眼睛中，Ras/MAPK通路的异位激活抑制了自然发生的细胞凋亡，并调节了促凋亡基因HID的转录。HID的零等位基因概括了RAS/MAPK的抗凋亡活性，提供了下调HID是RAS促进生存的重要机制的遗传学证据。
Activation of Ras inhibits apoptosis duringDrosophiladevelopment. Genetic evidence indicates that Ras antiapoptotic activity in the developing eye is regulated by theDrosophilaEGF receptor and operates through the Raf/MAPK pathway. Decreased activity of this pathway enhances, and increased activity suppresses, apoptosis induced by ectopic expression of the cell death regulatorsreaper(rpr) andhead involution defective(hid). In addition, ectopic activation of the Ras/MAPK pathway in the developing embryo and in the developing eye suppresses naturally occurring apoptosis and regulates the transcription of the proapoptotic genehid. Null alleles ofhidrecapitulate the antiapoptotic activities of Ras/MAPK, providing genetic evidence that downregulation ofhidis an important mechanism by which Ras promotes survival.