Effects of temporal lobe epilepsy on retrograde memory
Effects of temporal lobe epilepsy on retrograde memory
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DOI：
10.1111/j.1528-1167.2006.00476.x
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发表时间：
2006-03-01
期刊：
影响因子：
5.6
通讯作者：
Miller, L
中科院分区：
文献类型：
--
作者：
Lah, S;Lee, T;Miller, L
目的：在先前的研究中（Lah等人，2004），我们发现在接受颞叶切除术（TL）的患者逆行记忆缺陷。在这项研究中，我们着手确定是否存在这样的赤字手术前颞叶癫痫（TLE）患者。方法：记忆的公共和自传体的事实和事件进行了评估，在患者局灶性左侧（n = 15）或右侧（n = 14）TLE和健康对照组（n = 15）。癫痫和潜在的认知缺陷对逆行memory.Results的影响也进行了检查：左颞叶癫痫患者表现出跨域逆行记忆缺陷。右颞叶癫痫患者仅在自传体领域表现出回忆缺陷。发病年龄小（小于14岁）与回忆著名事件的困难更大相关，与接受单药治疗的患者相比，接受多药治疗的患者对自传体事件的回忆显着减少。在大多数情况下，过去的记忆缺陷与其他认知技能，特别是语言能力的损害，结论：在未手术的TLE患者，我们发现赤字逆行记忆后看到的TL，与赤字的模式受到影响的病变，抗惊厥药物，和单词查找赤字。与右侧TL后测试的患者不同，右侧TLE患者在回忆著名事件的细节方面没有困难，这提高了右侧TL导致这方面逆行记忆下降的可能性。
Purpose: In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory in patients who had undergone temporal lobectomy (TL). In this study, we set out to determine whether such deficits are present before surgery in patients with temporal lobe epilepsy (TLE).Methods: Memory for public and autobiographic facts and events was assessed in patients with focal left-sided (n = 15) or right-sided (n = 14) TLE and healthy control subjects (n = 15). The impact of epilepsy and underlying cognitive deficits on retrograde memory also was examined.Results: Patients with left TLE demonstrated retrograde memory deficits across domains. Patients with right TLE showed defective recall only in the autobiographic domain. Young age at onset (younger than 14 years) was associated with greater difficulties in recall of famous events, and patients receiving polytherapy had significantly reduced recall of autobiographic events compared with those receiving monotherapy. In most cases, deficient memory for the past was associated with impairments in other cognitive skills, especially language abilities.Conclusions: In unoperated-on patients with TLE, we found deficits in retrograde memory that were similar to those seen after TL, with the pattern of deficits being influenced by side of lesion, anticonvulsant medication, and word-finding deficits. Unlike patients tested after right TL, patients with right TLE did not have difficulty recalling details of famous events, which raises the possibility that right TL results in a decline in this aspect of retrograde memory.