Microneedle Arrays of Polyhydroxyalkanoate by Laser-Based Micromolding Technique.
Microneedle Arrays of Polyhydroxyalkanoate by Laser-Based Micromolding Technique.
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基于激光微成型技术的聚羟基脂肪酸酯微针阵列。
DOI：
10.1021/acsabm.0c00570
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发表时间：
2020
影响因子：
4.7
通讯作者：
E. Fortunato
中科院分区：
文献类型：
--
作者：
S. Silvestre;Diana Araújo;A. Marques;Carolina Pires;Mariana Matos;V. Alves;R. Martins;F. Freitas;M. Reis;E. Fortunato
尽管已经提出了许多递送系统来改善药物通过皮肤的渗透，但它们都存在一些局限性。这推动了对能够提供安全有效的透皮给药解决方案的创新系统的不断探索。据此，人们提出了微针（MN）阵列，它是皮下注射和透皮贴剂的混合组合。微针由微型针组成，可以通过简单、微创、无痛的途径刺穿皮肤，从而将药物和大分子输送到人体中。这项研究首次报道了使用生物基、可生物降解和生物相容性聚合物聚(3-羟基丁酸酯-co-3-羟基戊酸酯)、P(3HB-co-3HV)来制造基于生物聚合物的 MN 贴片。采用低成本、无掩模技术的直接激光写入技术制备了聚二甲基硅氧烷模具，并通过热固工艺生产可生物降解的 P(3HB-co-3HV) MN。最佳结果是在 30 W 的激光功率、0.15 m/s 的速度下以螺旋模型作为图案获得的。获得的 MN 长度为 0.69 毫米，直径为 0.33 毫米，非常适合无痛穿透皮肤。此外，所生产的 MN 具有良好的机械性能，并且能够成功浸渍荧光染料罗丹明 6G。这些特性使得 P(3HB-co-3HV) 成为开发具有改进功能的 MN 的有前途的材料。
Although many delivery systems have been proposed to improve drug permeation through the skin, all of them suffer from several limitations. This drives a continuous search for innovative systems that can provide safe and effective transdermal drug delivery solutions. In line with this, microneedle (MN) arrays, a hybrid combination of hypodermic injections and transdermal patches, have been proposed. MNs consist of microscale needles that can pierce the skin by a simple, minimally invasive, and painless route, enabling the transport of drugs and macromolecules into the human body. This study reports, for the first time, the use of a biobased, biodegradable, and biocompatible polymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate), P(3HB-co-3HV), for the fabrication of a biopolymer-based MN patch. Molds of poly(dimethylsiloxane) were prepared by direct laser writing technology, a low-cost and mask-less technology, and used to produce biodegradable P(3HB-co-3HV) MNs by a thermosetting process. The best results were obtained with a laser power of 30 W at 0.15 m/s with a spiral model as the pattern. The obtained MNs had a length of 0.69 mm and a diameter of 0.33 mm, ideal for painless penetration of the skin. Additionally, the produced MNs had good mechanical properties and the ability to be successfully impregnated with the fluorescent dye Rhodamine 6G. These features render P(3HB-co-3HV) a promising material for the development of MNs with improved functionality.