Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential
Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential
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DOI：
10.1038/sj.npp.1300376
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发表时间：
2004-04-01
影响因子：
7.6
通讯作者：
Siegel, SJ
中科院分区：
文献类型：
--
作者：
Maxwell, CR;Liang, YL;Siegel, SJ
听觉诱发电位已在多种动物模型中用于评估精神分裂症患者的信息处理障碍。以前的小鼠模型主要采用配对点击范式来评估听觉门控的瞬态测量。本研究采用刺激间隔（ISI）为0.25 ~ 8 s的刺激训练，评估慢性奥氮平和氟哌啶醇对听觉加工的影响。数据表明，奥氮平增加了听觉诱发电位的N40、P80和P20/N40分量的振幅，而氟哌啶醇没有这种作用。ISI范式还允许对小鼠诱发电位的几个组成部分进行评估，以评估那些显示与人类P50和N100相似的反应特性。数据表明，小鼠N40表现出与人类N100具有相同特征的ISI反应关系，而P20在本任务评估的ISI范围内与人类P50更为一致。这项研究表明，奥氮平可能有助于改善精神分裂症患者的N100损伤，而氟哌啶醇则没有。
Auditory evoked potentials have been used in a variety of animal models to assess information-processing impairments in schizophrenia. Previous mouse models have primarily employed a paired click paradigm to assess the transient measures of auditory gating. The current study uses stimulus trains at varied interstimulus intervals (ISI) between 0.25 and 8 s in mice to assess the effects of chronic olanzapine and haloperidol on auditory processing. Data indicate that olanzapine increases the amplitude of the N40, P80, and P20/N40 components of the auditory evoked potential, whereas haloperidol had no such effect. The ISI paradigm also allowed for an evaluation of several components of the mouse evoked potential to assess those that display response properties similar to the human P50 and N100. Data suggest that the mouse N40 displays an ISI response relationship that shares characteristics with the human N100, whereas the P20 appears more consistent with the human P50 across the ISI range evaluated in this task. This study suggests that olanzapine may help improve N100 impairments seen in schizophrenia, while haloperidol does not.