4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice.
4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice.
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DOI：
10.1016/j.canlet.2011.02.028
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发表时间：
2011-06
期刊：
影响因子：
9.7
通讯作者：
Hua Guo;Menghui Li;Peng Chen;D. Blake;Xiaoni Kong;X. Hao;R. Niu;Ning Zhang
中科院分区：
文献类型：
--
作者：
Hua Guo;Menghui Li;Peng Chen;D. Blake;Xiaoni Kong;X. Hao;R. Niu;Ning Zhang
转移在恶性肿瘤中仍然是一个令人敬畏的问题。本研究中，4-甲基-3-硝基-苯甲酸(4-甲基-3-硝基-苯甲酸，MNBA)对所有受试乳腺癌细胞系的细胞活力和细胞周期均无影响。然而，MNBA对乳腺癌细胞的处理在体外可以抑制EGF诱导的迁移和趋化。体内实验表明，MNBA和紫杉醇协同抑制乳腺癌SCID小鼠移植瘤的生长和转移。这些结果表明，MNBA是一种有效的癌细胞趋化抑制药，有可能发展成为一种新型的抗转移药物。
Metastasis remains a formidable problem in malignant tumors. In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. However, treatment with MNBA on breast cancer cells can inhibit EGF-induced migration and chemotaxis in vitro. In vivo assay demonstrated that MNBA and Paclitaxel synergistically inhibited tumor growth and metastasis in breast cancer SCID mice xenografts. These results suggest that MNBA is a potent inhibitor cancer cell chemotaxis and may be developed into a novel anti-metastasis drug.