Central and peripheral roles of vasopressin in the circadian defense of body hydration
Central and peripheral roles of vasopressin in the circadian defense of body hydration
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DOI：
10.1016/j.beem.2017.11.001
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发表时间：
2017-12-01
影响因子：
7.4
通讯作者：
Bourque, Charles W.
中科院分区：
文献类型：
--
作者：
Gizowski, Claire;Trudel, Eric;Bourque, Charles W.
加压素是一种由眼睛和大脑内特定神经元亚群合成的神经肽。对大鼠和小鼠的研究表明，投射到神经垂体的大细胞神经分泌细胞 (MNC) 产生的加压素被释放到血液循环中，在血液循环中充当抗利尿激素，促进肾脏对水的重吸收。此外，加压素是一种神经递质和神经调节剂，有助于主生物钟（即视交叉上核，SCN）内的计时，并且也被 SCN 神经元用作输出信号，以指导中枢介导的昼夜节律。在本章中，我们回顾了最近在啮齿类动物中进行的细胞和网络水平研究，这些研究深入了解了加压素的昼夜节律如何介导水摄入行为和肾脏保水行为的变化，从而保护身体在睡眠期间免受脱水。 (C) 2017 Elsevier Ltd. 保留所有权利。
Vasopressin is a neuropeptide synthesized by specific subsets of neurons within the eye and brain. Studies in rats and mice have shown that vasopressin produced by magnocellular neurosecretory cells (MNCs) that project to the neurohypophysis is released into the blood circulation where it serves as an antidiuretic hormone to promote water reabsorption from the kidney. Moreover vasopressin is a neurotransmitter and neuromodulator that contributes to time-keeping within the master circadian clock (i.e. the suprachiasmatic nucleus, SCN) and is also used as an output signal by SCN neurons to direct centrally mediated circadian rhythms. In this chapter, we review recent cellular and network level studies in rodents that have provided insight into how circadian rhythms in vasopressin mediate changes in water intake behavior and renal water conservation that protect the body against dehydration during sleep. (C) 2017 Elsevier Ltd. All rights reserved.