FUNCTIONAL-ORGANIZATION OF PRIMATE VISUAL-CORTEX REVEALED BY HIGH-RESOLUTION OPTICAL IMAGING
FUNCTIONAL-ORGANIZATION OF PRIMATE VISUAL-CORTEX REVEALED BY HIGH-RESOLUTION OPTICAL IMAGING
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DOI：
10.1126/science.2165630
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发表时间：
1990-07-27
期刊：
影响因子：
56.9
通讯作者：
GRINVALD, A
中科院分区：
文献类型：
--
作者：
TSO, DY;FROSTIG, RD;GRINVALD, A
开发了高空间分辨率光学成像系统来可视化体内大脑皮层活动。该方法基于活性依赖性内在信号，并且不使用电压敏感染料。对视觉刺激期间拍摄的活猴[猕猴]纹状 (V1) 和纹状外 (V2) 视觉皮层的图像进行分析，以生成具有各种功能特性的细胞分布图。 V1 富含细胞色素氧化酶的斑点和 V2 的条纹在活体大脑中成像。在 V2 中，没有看到眼部优势组织，而定向调节不良的区域与每个其他细胞色素氧化酶条纹共定位。 V2 其他区域的方向调整似乎被组织为比 V1 中更大且更均匀的模块。
A high spatial resolution optical imaging sytem was developed to visualize cerebral cortical activity in vivo. This method is based on activity-dependent intrinsic signals and does not use voltage-sensitive dyes. Images of the living monkey [macaque] striate (V1) and extrastriate (V2) visual cortex, taken during visual stimulation, were analyzed to yield maps of the distribution of cells with various functional properties. The cytochrome oxidase-rich blobs of V1 and the stripes of V2 were imaged in the living brain. In V2, no ocular dominance organization was seen, while regions of poor orientation tuning colocalized to every other cytochrome oxidase stripe. The orientation tuning of other regions of V2 appeared organized as modules that are larger and more uniform than those in V1.