Apolipoproteins in the brain: implications for neurological and psychiatric disorders.
Apolipoproteins in the brain: implications for neurological and psychiatric disorders.
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DOI：
10.2217/clp.10.37
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发表时间：
2010-08-01
影响因子：
--
通讯作者：
Garner B
中科院分区：
文献类型：
--
作者：
Elliott DA;Weickert CS;Garner B
脑是体内最富含脂质的器官，并且由于血脑屏障的不可渗透性，该器官内的脂质和脂蛋白代谢与身体的其余部分不同。载脂蛋白在CNS内的脂质转运和代谢中发挥着公认的作用;然而，有证据表明，它们还实现了许多超出脂质转运的功能，并且对健康的脑功能至关重要。载脂蛋白在脑生理学中的重要性在遗传学研究中得到强调，其中载脂蛋白基因多态性已被确定为几种神经系统疾病的风险因素。此外，脑载脂蛋白的表达在几种脑疾病中显著改变。本文的目的是提供一个最新的评估主要载脂蛋白在大脑中发现（ApoE，ApoJ，ApoD和ApoA-I），涵盖其拟议的作用和影响其表达水平的因素。特别强调的是与神经和精神疾病的关联。
The brain is the most lipid-rich organ in the body and, owing to the impermeable nature of the blood–brain barrier, lipid and lipoprotein metabolism within this organ is distinct from the rest of the body. Apolipoproteins play a well-established role in the transport and metabolism of lipids within the CNS; however, evidence is emerging that they also fulfill a number of functions that extend beyond lipid transport and are critical for healthy brain function. The importance of apolipoproteins in brain physiology is highlighted by genetic studies, where apolipoprotein gene polymorphisms have been identified as risk factors for several neurological diseases. Furthermore, the expression of brain apolipoproteins is significantly altered in several brain disorders. The purpose of this article is to provide an up-to-date assessment of the major apolipoproteins found in the brain (ApoE, ApoJ, ApoD and ApoA-I), covering their proposed roles and the factors influencing their level of expression. Particular emphasis is placed on associations with neurological and psychiatric disorders.