Cytokines in the systemic inflammatory response syndrome: a review
Cytokines in the systemic inflammatory response syndrome: a review
复制标题
全身炎症反应综合征中的细胞因子：综述
DOI：
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Terence Gourlay
中科院分区：
文献类型：
--
作者：
Usman Jaffer;R. Wade;Terence Gourlay
简介 接受大手术、脓毒症、重大创伤或体外循环后的患者会表现出全身炎症反应。这种炎症反应涉及一系列复杂的炎症多肽分子，称为细胞因子。人们普遍认为，这些细胞因子释放的局部控制丧失会导致全身炎症和潜在的有害后果，包括全身炎症反应综合征、多器官功能障碍综合征、休克和死亡。方法 在 Medline 数据库中检索有关 SIRS 发生机制和改变炎症反应的潜在靶点的文献。我们专注于细胞因子吸附的新疗法，作为一种有前景的去除技术。结果来自人类研究和实验动物模型的积累数据表明，促炎细胞因子和抗炎细胞因子都会在各种起始刺激后释放，包括内毒素释放、补体激活、缺血再灌注损伤等。讨论促炎细胞因子和抗炎细胞因子以复杂且不可预测的方式相互作用，影响免疫系统并最终引起多种终末器官效应。细胞因子吸附疗法为改善全身炎症反应综合征的预后提供了潜在的解决方案。
Introduction Patients subject to major surgery, suffering sepsis, major trauma, or following cardiopulmonary bypass exhibit a systemic inflammatory response. This inflammatory response involves a complex array of inflammatory polypeptide molecules known as cytokines. It is well accepted that the loss of local control of the release of these cytokines leads to systemic inflammation and potentially deleterious consequences including the Systemic Inflammatory Response Syndrome, Multi-Organ Dysfunction Syndrome, shock and death. Methods The Medline database was searched for literature on mechanisms involved in the development of SIRS and potential targets for modifying the inflammatory response. We focus on the novel therapy of cytokine adsorption as a promising removal technology. Results Accumulating data from human studies and experimental animal models suggests that both pro- and anti- inflammatory cytokines are released following a variety of initiating stimuli including endotoxin release, complement activation, ischaemia reperfusion injury and others. Discussion Pro-and anti-inflammatory cytokines interact in a complex and unpredictable manner to influence the immune system and eventually cause multiple end organ effects. Cytokine adsorption therapy provides a potential solution to improving outcomes following Systemic Inflammatory Response Syndrome.
DOI：
10.1152/ajpheart.1999.277.4.h1641
发表时间：
1999-10-01
影响因子：
4.8
作者：
Kan, H;Xie, ZR;Finkel, MS
通讯作者：
Finkel, MS