Quantitative Susceptibility Mapping of Multiple Sclerosis Lesions at Various Ages
Quantitative Susceptibility Mapping of Multiple Sclerosis Lesions at Various Ages
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DOI：
10.1148/radiol.13130353
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发表时间：
2014-04-01
期刊：
影响因子：
19.7
通讯作者：
Wang, Yi
中科院分区：
文献类型：
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作者：
Chen, Weiwei;Gauthier, Susan A.;Wang, Yi
目的：目的：应用定量磁敏感图（QSM）和常规磁共振成像（MRI）对不同年龄的多发性硬化（MS）患者进行评估（九男二十三女; 39.3岁+/- 10.9），接受了两次MR检查（间隔，0.43年+/- 0.16），从2011年8月至2012年8月，采用三维梯度回波序列。为了估计MS病变的年龄，研究了在研究检查前0.3-10.6年进行的MR检查。T2加权图像上的高信号用于定义MS病变。从梯度回波数据重建QSM图像。从QSM图像中获得MS病变的易感性和时间变化率。病变敏感性进行了分析，t检验与群内相关调整和Bonferroni校正在多重comparing.Results：32例患者的MR成像描绘了598个MS病灶，其中162个病灶（27.1%）在23例患者的年龄可测量和6个（1.0%），只有在QSM可见。相对于正常外观白色物质（NAWM），急性增强病变的灵敏度为0.53 ppb +/- 6 3.34，早期至中期非增强病变为38.43 ppb +/- 13.0（阳性; P <0.01），慢性非增强病变为4.67 ppb +/- 3.18。相对于脑脊液的敏感性变化的时间率为急性增强病变12.49 ppb/月+/- 3.15，早期至中期非增强病变1.27 ppb/月+/- 2.31，慢性非增强病变-0.004 ppb/月+/- 0。MS病灶的磁化率随其由增强到非增强而迅速增加，在最初几年内相对于NAWM达到较高的磁化率值（约4年），并逐渐消散回的敏感性相似的NAWM，随着年龄的增长，这可能会提供新的见解MS病变的病理生理特征。(C)RSNA，2013年
Purpose: To assess multiple sclerosis (MS) lesions at various ages by using quantitative susceptibility mapping (QSM) and conventional magnetic resonance (MR) imaging.Materials and Methods: Retrospectively selected were 32 clinically confirmed MS patients (nine men and 23 women; 39.3 years +/- 10.9) who underwent two MR examinations (interval, 0.43 years +/- 0.16) with three-dimensional gradient-echo sequence from August 2011 to August 2012. To estimate the ages of MS lesions, MR examinations performed 0.3-10.6 years before study examinations were studied. Hyperintensity on T2-weighted images was used to define MS lesions. QSM images were reconstructed from gradient-echo data. Susceptibility of MS lesions and temporal rates of change were obtained from QSM images. Lesion susceptibilities were analyzed by t test with intracluster correlation adjustment and Bonferroni correction in multiple comparisons.Results: MR imaging of 32 patients depicted 598 MS lesions, of which 162 lesions (27.1%) in 23 patients were age measurable and six (1.0%) were only visible at QSM. The susceptibilities relative to normal-appearing white matter (NAWM) were 0.53 ppb +/- 6 3.34 for acute enhanced lesions, 38.43 ppb +/- 13.0 (positive; P < .01) for early to intermediately aged nonenhanced lesions, and 4.67 ppb +/- 3.18 for chronic nonenhanced lesions. Temporal rates of susceptibility changes relative to cerebrospinal fluid were 12.49 ppb/ month +/- 3.15 for acute enhanced lesions, 1.27 ppb/ month +/- 2.31 for early to intermediately aged nonenhanced lesions, and -0.004 ppb/ month +/- 0 for chronic nonenhanced lesions.Conclusion: Magnetic susceptibility of MS lesions increased rapidly as it changed from enhanced to nonenhanced, it attained a high susceptibility value relative to NAWM during its initial few years (approximately 4 years), and it gradually dissipated back to susceptibility similar to that of NAWM as it aged, which may provide new insight into pathophysiologic features of MS lesions. (C) RSNA, 2013