Mortality in Parkinson's disease and its association with dementia and depression
Mortality in Parkinson's disease and its association with dementia and depression
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DOI：
10.1111/j.1600-0404.2004.00292.x
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发表时间：
2004-08-01
影响因子：
3.5
通讯作者：
Spokes, EGS
中科院分区：
文献类型：
--
作者：
Hughes, TA;Ross, HF;Spokes, EGS
目的：比较帕金森病（PD）与非PD对照组的死亡率，并评估死亡率与PD特征之间的关系。材料和方法：90例PD患者和50例对照组，随访11年后确定死亡率。结果：PD患者与对照组相比死亡率的风险比（HR）为1.64（95%CI：1.21 - 2.23）。多因素分析显示，年龄、痴呆和抑郁是死亡率的独立预测因素，而发病年龄和神经系统症状的严重程度则不是。年龄的HR为1.09（95% CI：1.05 - 1.13），痴呆的HR为1.94（95% CI：1.26 - 2.99），抑郁的HR为2.66（95% CI：1.59 - 4.44）。结论：PD患者的死亡率较对照组增加。心理因素是PD患者死亡率的重要预测因素。
Objective - To compare the mortality rate in Parkinson's disease (PD) with a control group without PD, and to assess the relationship between mortality and features of PD. Material and methods - Ninety PD patients and 50 controls, mortality ascertained at 11 years follow-up. Results - The hazard ratio (HR) for mortality in PD patients compared with controls was 1.64 (95% CI: 1.21-2.23). Multivariate analysis showed age, dementia and depression were independent predictors of mortality but age at onset of PD and severity of neurological symptoms were not. The HR for age was 1.09 (95% CI: 1.05-1.13), for dementia 1.94 (95% CI: 1.26-2.99), and for depression 2.66 (95% CI: 1.59-4.44). Conclusion - Mortality in PD is increased compared with controls. Psychological variables are important predictors of mortality in PD.