Breakthrough Trichosporon asahii fungemia in neutropenic patient with acute leukemia while receiving caspofungin
Breakthrough Trichosporon asahii fungemia in neutropenic patient with acute leukemia while receiving caspofungin
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DOI：
10.1007/s15010-007-6278-6
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发表时间：
2008-02-01
期刊：
影响因子：
7.5
通讯作者：
Aydin, F.
中科院分区：
文献类型：
--
作者：
Bayramoglu, G.;Sonmez, M.;Aydin, F.
一名47岁的男性，新诊断为急性髓细胞白血病和非胰岛素依赖型糖尿病，在接受卡泊芬净作为经验性抗真菌治疗时发生了阿萨希丝孢酵母菌血症。诊断是根据反复分离T。Asahii血培养三次。尽管使用阿替霉素B和伏立康唑治疗，患者仍死亡。体外抗真菌活性测定结果表明，T. Asahii分离株只有在患者死亡后才可获得。体外抗真菌药敏试验显示，该丝孢酵母菌株的卡泊芬净和阿替霉素B最小抑菌浓度（MIC）值较高（MIC分别为16 μ g/ml和> 32 μ g/ml）。氟康唑、伊曲康唑和伏立康唑在体外表现出较低的MIC（MIC，4 μ g/ml，0.5 μ g/ml，
A 47-year-old man with newly diagnosed acute myeloblastic leukemia and non-insulin-dependent diabetes mellitus developed Trichosporon asahii fungemia while receiving caspofungin as empirical antifungal therapy. The diagnosis was based on repeated isolation of T. asahii in culture of blood for three times. Despite treatment with amphotericin B and voriconazole, the patient died. The in vitro antifungal susceptibilities of the T. asahii isolates were only available after the patient died. In vitro antifungal susceptibility tests showed high caspofungin and amphotericin B minimal inhibitory concentrations (MICs) value for this Trichosporon strain (MICs, 16 mu g/ml, and > 32 mu g/ml, respectively). Fluconazole, itraconazole, and voriconazole exhibited low MICs in vitro (MICs, 4 mu g/ml, 0.5 mu g/ml, and