Animal models of stress urinary incontinence.
Animal models of stress urinary incontinence.
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DOI：
10.1007/978-3-642-16499-6_3
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发表时间：
2011
影响因子：
--
通讯作者：
Damaser, Margot S
中科院分区：
文献类型：
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作者：
Jiang, Hai-Hong;Damaser, Margot S
压力性尿失禁（Stress urinary incontinence， SUI）是一种常见的健康问题，严重影响全球女性的生活质量。模拟SUI的动物模型能够以可控的方式评估SUI的危险因素机制，包括分娩损伤，并能够对SUI的新治疗和疗法进行临床前测试。目前正在利用模拟分娩的动物模型来确定导致SUI的分娩母亲损伤的机制，目的是开发预防性治疗方法。在动物中评估SUI的方法模仿临床使用的诊断方法已经开发出来评估动物模型。使用这些动物模型来测试创新的治疗策略有可能改善SUI的临床管理。本章综述了现有的SUI动物模型，以及在动物模型中评估SUI的方法，以及在这些模型上测试的潜在治疗方法。
Stress urinary incontinence (SUI) is a common health problem significantly affecting the quality of life of women worldwide. Animal models that simulate SUI enable the assessment of the mechanism of risk factors for SUI in a controlled fashion, including childbirth injuries, and enable preclinical testing of new treatments and therapies for SUI. Animal models that simulate childbirth are presently being utilized to determine the mechanisms of the maternal injuries of childbirth that lead to SUI with the goal of developing prophylactic treatments. Methods of assessing SUI in animals that mimic diagnostic methods used clinically have been developed to evaluate the animal models. Use of these animal models to test innovative treatment strategies has the potential to improve clinical management of SUI. This chapter provides a review of the available animal models of SUI, as well as a review of the methods of assessing SUI in animal models, and potential treatments that have been tested on these models.