Signaling Pathways in the Specification of Arteries and Veins
Signaling Pathways in the Specification of Arteries and Veins
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DOI：
10.1161/atvbaha.114.303218
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发表时间：
2014-11-01
影响因子：
8.7
通讯作者：
Dejana, Elisabetta
中科院分区：
文献类型：
--
作者：
Corada, Monica;Morini, Marco Francesco;Dejana, Elisabetta
内皮细胞的动脉和静脉特性的建立对于血管树的正确解剖结构和功能是至关重要的。动脉和静脉内皮细胞的特化由遗传因素决定，尽管周围的细胞和血液动力学力量也可能有助于血管重塑。本文就内皮细胞分化的信号通路及相关转录因子的研究进展作一综述。我们将讨论，特别是Wnt，Sox和Notch途径的上游和下游效应物的作用。对协调内皮分化的分子机制的理解可能对诸如动脉粥样硬化、动静脉畸形、动脉瘤等疾病具有治疗相关性。
The establishment of arterial and venous identity of endothelial cells is critical for the proper anatomic configuration and function of the vascular tree. Arterial and venous specification of endothelial cells is determined by genetic factors, although surrounding cells and hemodynamic forces may also contribute to vascular remodeling. This review provides an overview of the signaling pathways and related transcription factors implicated in differentiation of endothelial cells. We will discuss, in particular, the role of upstream and downstream effectors of Wnt, Sox, and Notch pathways. The understanding of the molecular mechanisms that orchestrate endothelial differentiation may have therapeutic relevance for diseases such as atherosclerosis, arteriovenous malformations, aneurysms, and others.