p53 activation and mitochondria-mediated pathway are involved during hanging death-induced neuronal cell apoptosis in dentate gyrus region of the rat brain.
p53 activation and mitochondria-mediated pathway are involved during hanging death-induced neuronal cell apoptosis in dentate gyrus region of the rat brain.
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DOI：
10.1186/2193-1801-2-407
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Bhattacharyya CN
中科院分区：
文献类型：
--
作者：
Khatun S;Chaube SK;Bhattacharyya CN
这项研究的目的是了解上吊死亡(HD)引起的大脑中的分子事件。动物接受颈椎脱位(CD)或HD。分别于死后0、1、3、6、12h取脑。检测脑组织P53、Bax蛋白表达、细胞色素c浓度、半胱氨酸天冬氨酸氨基转移酶活性及DNA片段化。与CD组相比，HD组早期(0~6h)P53、Bax蛋白表达、细胞色素c浓度、caspase活性及DNA片段化均显著增加，而Cd组在3h及以后均出现坏死。这些数据支持HD诱导神经细胞凋亡，部分是通过线粒体介导的途径。这些数据还表明，神经元凋亡可能是一个潜在的标志物，并有助于HD的法医学研究。
The goal of this study was to understand the molecular event in the brain caused by hanging death (HD). Animals were subjected to either cervical dislocation (CD) or HD. Brain was collected at various times (0, 1, 3, 6 and 12 h) after death. Brain expression of p53 and Bax, cytochrome c concentration, caspases activity and DNA fragmentation were analyzed. Compared to that of CD, HD increased p53 and Bax proteins expressions, cytochrome c concentration, caspases activity and DNA fragmentation during the early period (0–6 h) of HD, whereas CD induced necrosis 3 h post- CD and thereafter. These data support that HD induces neuronal cell apoptosis, in part, through mitochondria-mediated pathways. These data also suggest that neuronal apoptosis could be a potential marker and an aid to forensic science of HD.
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影响因子：
3.8
作者：
Natesan, Senthilkumar;Kataria, J. M.;Sylvester, A.
通讯作者：
Sylvester, A.
影响因子：
3.6
作者：
Mouw, G;Zechel, JL;Ratcheson, RA
通讯作者：
Ratcheson, RA
影响因子：
11.4
作者：
Brady, HJM;Salomons, GS;Berns, AJM
通讯作者：
Berns, AJM
DOI：
10.1073/pnas.96.10.5752
发表时间：
1999-05-11
影响因子：
11.1
作者：
Krajewski, S;Krajewska, M;Reed, JC
通讯作者：
Reed, JC
影响因子：
4.4
作者：
Chan, PH
通讯作者：
Chan, PH