The Role of Sphingolipids and Sphingosine-1-phosphate-Sphingosine-1-phosphate-receptor Signaling in Psoriasis.
The Role of Sphingolipids and Sphingosine-1-phosphate-Sphingosine-1-phosphate-receptor Signaling in Psoriasis.
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牛皮癣是一种持久的皮肤状况，其特征是皮肤表面发红和厚银鳞片。它涉及各种皮肤细胞，包括角质形成细胞、树突细胞、T淋巴细胞和中性粒细胞。牛皮癣的治疗范围从局部到全身治疗，但它们只能缓解症状，不能提供根本的治愈。此外，全身治疗的缺点是抑制整个身体的免疫系统。因此，需要一种对免疫系统影响最小的新治疗策略。最近的研究表明，鞘脂代谢产物，特别是神经酰胺和鞘氨醇-1-磷酸（S1 P），在银屑病中起着重要作用。特异性S1 P-S1 P受体（S1 PR）信号通路已被确定为银屑病炎症的关键。基于这些发现，研究了S1 PR调节剂，并发现其可改善银屑病炎症。本文将讨论鞘脂的代谢途径，这些代谢产物的个体功能，以及它们作为银屑病新治疗方法的潜力。
Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin’s surface. It involves various skin cells, including keratinocytes, dendritic cells, T lymphocytes, and neutrophils. The treatments for psoriasis range from topical to systemic therapies, but they only alleviate the symptoms and do not provide a fundamental cure. Moreover, systemic treatments have the disadvantage of suppressing the entire body’s immune system. Therefore, a new treatment strategy with minimal impact on the immune system is required. Recent studies have shown that sphingolipid metabolites, particularly ceramide and sphingosine-1-phosphate (S1P), play a significant role in psoriasis. Specific S1P–S1P-receptor (S1PR) signaling pathways have been identified as crucial to psoriasis inflammation. Based on these findings, S1PR modulators have been investigated and have been found to improve psoriasis inflammation. This review will discuss the metabolic pathways of sphingolipids, the individual functions of these metabolites, and their potential as a new therapeutic approach to psoriasis.
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影响因子：
5.3
作者：
Chen, Tianyi;Song, Peiyang;He, Min;Rui, Shunli;Duan, Xiaodong;Ma, Yu;Armstrong, David G.;Deng, Wuquan
通讯作者：
Deng, Wuquan
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1
作者：
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Gregory, CR
影响因子：
13.8
作者：
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通讯作者：
Menter, Alan
影响因子：
4.4
作者：
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通讯作者：
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影响因子：
9
作者：
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