Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats.
Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats.
复制标题
大鼠慢性儿茶酚胺输注期间的高血压和心血管肥大。
DOI：
10.1016/0024-3205(83)90410-1
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发表时间：
1983
期刊：
影响因子：
6.1
通讯作者：
Schanberg,SM
中科院分区：
文献类型：
--
作者：
Johnson,MD;Grignolo,A;Kuhn,CM;Schanberg,SM
慢性持续皮下注射去甲肾上腺素（NE）或肾上腺素（Epi）可使大鼠收缩压（SBP）迅速升高40 mm Hg。压力在输注期间保持较高，但在输注终止后迅速恢复至对照水平。开始NE输注后2天内，胸主动脉、腹主动脉和心脏明显肥大，输注5天后达到平台期。多胺生物合成的限速酶组织鸟氨酸脱羧酶（ODC）的活性，升高的发病前的组织肥大，并返回到控制水平的同时停止加速组织生长。它的结论是高血压动物模型中的高血压是依赖于持续存在的外源性儿茶酚胺，和显着的心血管肥大本身是不足以维持高血压。血管ODC活性的升高和降低与其他组织中ODC活性升高是肥大的必然早期事件的报道一致。
Chronic continuous infusion of norepinephrine (NE) or epinephrine (Epi) subcutaneously in rats resulted in a rapid elevation of systolic blood pressure (SBP) by 40 mm Hg. Pressure remained high for the duration of the infusion but rapidly returned to control levels after its termination. Pronounced hypertrophy of the thoracic aorta, abdominal aorta and heart was evident within 2 days of the initiation of NE infusion and a plateau was attained by 5 days of infusion. The activity of tissue ornithine decarboxylase (ODC), the rate limiting enzyme in polyamine biosynthesis, was elevated preceeding the onset of tissue hypertrophy, and returned to control levels coincidentally with the cessation of accelerated tissue growth. It is concluded that high blood pressure in this animal model of hypertension is dependent upon the continued presence of exogenous catecholamine, and that pronounced cardiovascular hypertrophy per se is not sufficient to maintain the hypertension. The elevation and decline of vascular ODC activity is consistent with reports that in other tissues an elevation of ODC activity is an obligatory early event in hypertrophy.