Modulation of Fgf8 activity during vertebrate brain development
Modulation of Fgf8 activity during vertebrate brain development
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DOI：
10.1016/j.brainresrev.2004.12.035
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Martinez, S
中科院分区：
文献类型：
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作者：
Echevarria, D;Belo, JA;Martinez, S
近年来，人们非常重视对脑发育过程中纤维母细胞生长因子（FGF）信号精确调控的研究。这种调控部分是通过调节元件实现的，这些调节元件通过特定的分子信号通路决定编码不同FGF配体的基因的表达区域和水平。对于在神经管中参与相邻区域正确模式形成（被称为神经管模式的次级组织者）的区域中此类机制的运作，人们有了新的认识。在这篇小型综述中，我们打算总结关于在发育中的脊椎动物大脑中调控Fgf8信号活性的有效调节剂的最新证据和新出现的结论，我们将注意力集中在最著名的次级组织者——峡部组织者上。（c）2005爱思唯尔有限公司。保留所有权利。
In recent years much emphasis has been placed on investigation of the precise control of FGF signaling during brain development. Such control is achieved in part by regulatory elements that determine the domains and levels of expression of genes coding for the diverse FGF ligands via specific molecular signaling pathways. There is new knowledge on the operation of such mechanisms in regions of the neural tube involved in the correct patterning of adjacent territories (known as secondary organizers of neural tube pattern). In the present minireview we intend to summarize recent evidence and emerging conclusions on potent modulators that govern the activity of Fgf8 signals in the developing vertebrate brain, focusing our attention on the best known secondary organizer, the isthmic organizer. (c) 2005 Elsevier B.V. All rights reserved.