The differential role of Jak/STAT signaling in retinal degeneration.
The differential role of Jak/STAT signaling in retinal degeneration.
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DOI：
10.1007/978-1-4419-1399-9_69
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发表时间：
2009-04
影响因子：
--
通讯作者：
C. Lange;M. Thiersch;M. Samardzija;C. Grimm
中科院分区：
文献类型：
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作者：
C. Lange;M. Thiersch;M. Samardzija;C. Grimm
视网膜变性疾病是人类严重视力损害或失明的主要原因。为了开发治疗策略，了解疾病进展过程中发生的分子机制尤为重要。Janus激酶/信号转导子和转录激活子（Jak/STAT）信号通路的基因和蛋白已被证明在视网膜变性（RD）模型中起重要作用。在这里，我们研究了参与Jak/STAT途径的其他基因在诱导（光照）和遗传（rd 1小鼠）RD模型中的表达。我们发现，STAT mRNA以及Jak 2/shp-1通路在两种模型中受到差异调节。相反，我们发现Jak 3 mRNA在rd 1小鼠的光损伤和退行性视网膜中均上调。这种对可能不同的凋亡刺激的共同回答表明Jak 3在受损的视网膜中起着重要作用，因此可能对进一步的研究感兴趣。
Retinal degenerative diseases are a major cause of severe visual impairment or blindness in humans. To develop therapeutic strategies it is of particular importance to understand the molecular mechanisms taking place during the progression of the disease. Genes and proteins of the Janus kinase/Signal Transducer and Activator of Transcription (Jak/STAT) signaling pathway have been shown to play an important role in models of retinal degeneration (RD). Here we investigated the expression of additional genes involved in the Jak/STAT pathway in an induced (light exposure) and an inherited (rd1 mouse) model of RD. We show that STAT mRNAs as well as the Jak2/shp-1 pathway are differentially regulated in the two models. In contrast, we show that Jak3 mRNA is upregulated in both, the light damaged and the degenerative retina of the rd1 mouse. This common answer to probably different apoptotic stimuli suggests a prominent role for Jak3 in the damaged retina and could therefore be interesting for further investigations.