Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque
Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque
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DOI：
10.1038/5739
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发表时间：
1999-02-01
影响因子：
25
通讯作者：
Shadlen, MN
中科院分区：
文献类型：
--
作者：
Kim, JN;Shadlen, MN
为了进行视觉辨别，大脑必须从视网膜提取相关信息，在视觉皮层中表示适当的变量，并读出该表示以决定两个或多个选项中哪一个更有可能。我们在恒河猴执行运动辨别任务时记录了其背外侧前额叶皮层（区域 8 和 46）的神经元。猴子通过适当的眼球运动来表明其对方向的判断。当猴子看到运动刺激时，神经反应预测了猴子随后的目光转移，从而预测了方向。该反应包括高水平动眼神经信号和反映运动强度和方向的较弱视觉感觉信号的混合。感觉统合和运动规划的结合可以反映视觉运动信息到方向分类决策的转换，从而深入了解简单认知行为背后的神经计算。
To make a visual discrimination, the brain must extract relevant information from the retina, represent appropriate variables in the visual cortex and read out this representation to decide which of two or more alternatives is more likely. We recorded from neurons in the dorsolateral prefrontal cortex (areas 8 and 46) of the rhesus monkey while it performed a motion discrimination task. The monkey indicated its judgment of direction by making appropriate eye movements. As the monkey viewed the motion stimulus, the neural response predicted the monkey's subsequent gaze shift, hence its judgment of direction. The response comprised a mixture of high-level oculomotor signals and weaker visual sensory signals that reflected the strength and direction of motion. This combination of sensory integration and motor planning could reflect the conversion of visual motion information into a categorical decision about direction and thus give insight into the neural computations behind a simple cognitive act.