Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: a meta-analysis
Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: a meta-analysis
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DOI：
10.1016/s0140-6736(00)02528-9
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发表时间：
2000-07-29
期刊：
影响因子：
168.9
通讯作者：
Piedbois, P
中科院分区：
文献类型：
--
作者：
Buyse, M;Thirion, P;Piedbois, P
背景 晚期结直肠癌的治疗已取得显着进展。然而，缓解率的提高并不总能转化为显着的生存效益。因此，人们对肿瘤反应作为临床终点的有效性提出了质疑。 方法 这项荟萃分析是对 3791 名患者的个人数据进行的，这些患者参加了 25 项随机试验，这些试验涉及标准静脉推注氟嘧啶一线治疗与实验治疗（氟尿嘧啶加亚叶酸、氟尿嘧啶加甲氨蝶呤、氟尿嘧啶连续输注或肝动脉输注氟尿苷），分析是有意进行的研究结果与推注氟嘧啶相比，实验性氟嘧啶导致显着更高的肿瘤缓解率（2031 名患者中有 454 名患者有反应，而 1760 名患者中有 209 名患者有反应；比值比 0.48 [95% CI 0.40-0.57]，p
Background Treatment of advanced colorectal cancer has progressed substantially. However, improvements in response rates have not always translated into significant survival benefits. Doubts have therefore been raised about the usefulness of tumour response as a clinical endpoint.Methods This meta-analysis was done on individual data from 3791 patients enrolled in 25 randomised trials of first-line treatment with standard bolus intravenous fluoropyrimidines versus experimental treatments (fluorouracil plus leucovorin, fluorouracil plus methotrexate, fluorouracil continuous infusion, or hepatic-arterial infusion of floxuridine), Analyses were by intention to treat.Findings Compared with bolus fluoropyrimidines, experimental fluoropyrimidines led to significantly higher tumour response rates (454 responses among 2031 patients vs 209 among 1760; odds ratio 0.48 [95% CI 0.40-0.57], p