Mechanisms of genome evolution of Streptococcus.
Mechanisms of genome evolution of Streptococcus.
复制标题
链球菌基因组演化的机理。
DOI：
10.1016/j.meegid.2014.11.007
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发表时间：
2015-07
影响因子：
3.2
通讯作者：
Hanage, William P.
中科院分区：
文献类型：
--
作者：
Andam, Cheryl P.;Hanage, William P.
链球菌属包含 104 种公认的物种，其中许多与人类或动物宿主有关。该组中全球流行的人类病原体是肺炎链球菌（肺炎球菌）。它不仅是上呼吸道的常见居民，也是中耳炎、肺炎、菌血症和脑膜炎的主要原因，在全球范围内造成很高的发病率和死亡率。最近的研究结果表明，重组和选择在推动不同肺炎球菌谱系的种群动态和进化方面的重要性，使它们能够成功地逃避疫苗接种和抗生素治疗等选择性压力的影响。我们强调肺炎球菌通过血清型替换、荚膜转换和抗生素抗性基因水平基因转移（HGT）等过程应对这些压力的能力。控制这种病原体的挑战还在于不同肺炎球菌谱系之间特殊的遗传和表型变异，特别是在其致病性和对当前治疗策略的耐药性方面。肺炎球菌结合疫苗仅针对 90 多种肺炎球菌血清型中的一小部分，其广泛使用为我们提供了一个独特的机会来阐明选择和重组过程如何相互作用，从而在肺炎球菌基因组中产生显着水平的可塑性和异质性。这些过程还在多重耐药菌株的出现和传播中发挥着重要作用，这继续对疾病控制和/或根除构成挑战。在不同空间和时间尺度上应用基因组方法群体将有助于改进控制这种全球病原体以及其他潜在致病性链球菌的策略。
The genus Streptococcus contains 104 recognized species, many of which are associated with human or animal hosts. A globally prevalent human pathogen in this group is Streptococcus pneumoniae (the pneumococcus). While being a common resident of the upper respiratory tract, it is also a major cause of otitis media, pneumonia, bacteremia and meningitis, accounting for a high burden of morbidity and mortality worldwide. Recent findings demonstrate the importance of recombination and selection in driving the population dynamics and evolution of different pneumococcal lineages, allowing them to successfully evade the impacts of selective pressures such as vaccination and antibiotic treatment. We highlight the ability of pneumococci to respond to these pressures through processes including serotype replacement, capsular switching and horizontal gene transfer (HGT) of antibiotic resistance genes. The challenge in controlling this pathogen also lies in the exceptional genetic and phenotypic variation among different pneumococcal lineages, particularly in terms of their pathogenicity and resistance to current therapeutic strategies. The widespread use of pneumococcal conjugate vaccines, which target only a small subset of the more than 90 pneumococcal serotypes, provides us with a unique opportunity to elucidate how the processes of selection and recombination interact to generate a remarkable level of plasticity and heterogeneity in the pneumococcal genome. These processes also play an important role in the emergence and spread of multi-resistant strains, which continues to pose a challenge in disease control and/or eradication. The application of population of genomic approaches at different spatial and temporal scales will help improve strategies to control this global pathogen, and potentially other pathogenic streptococci.
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影响因子：
6.4
作者：
Beall, Bernard W.;Gertz, Robert E.;Brueggemann, Angela B.
通讯作者：
Brueggemann, Angela B.
影响因子：
6.7
作者：
Brueggemann, Angela B.;Pai, Rekha;Beall, Bernard
通讯作者：
Beall, Bernard
影响因子：
4.2
作者：
Bowers JR;Driebe EM;Nibecker JL;Wojack BR;Sarovich DS;Wong AH;Brzoska PM;Hubert N;Knadler A;Watson LM;Wagner DM;Furtado MR;Saubolle M;Engelthaler DM;Keim PS
通讯作者：
Keim PS
影响因子：
5.4
作者：
Croucher NJ;Hanage WP;Harris SR;McGee L;van der Linden M;de Lencastre H;Sá-Leão R;Song JH;Ko KS;Beall B;Klugman KP;Parkhill J;Tomasz A;Kristinsson KG;Bentley SD
通讯作者：
Bentley SD
影响因子：
5.1
作者：
Domenech, Mirian;Garcia, Ernesto;Moscoso, Miriam
通讯作者：
Moscoso, Miriam