The European tiered approach for virucidal efficacy testing - rationale for rapidly selecting disinfectants against emerging and re-emerging viral diseases.
The European tiered approach for virucidal efficacy testing - rationale for rapidly selecting disinfectants against emerging and re-emerging viral diseases.
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DOI：
10.2807/1560-7917.es.2021.26.3.2000708
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Steinhauer K
中科院分区：
文献类型：
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作者：
Eggers M;Schwebke I;Suchomel M;Fotheringham V;Gebel J;Meyer B;Morace G;Roedger HJ;Roques C;Visa P;Steinhauer K
面对新出现的病毒爆发，如严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)，快速反应时间是控制传播的关键。开发抗病毒药物和疫苗以及实施疫苗接种运动需要时间。因此，迅速隔离病例和识别病例密切接触者以及口罩、身体距离、手卫生、表面消毒和空气控制等预防措施对于降低传播风险至关重要。在这种情况下，应使用已证明对暴发病毒有效的消毒剂和防腐剂。然而，杀生制剂相当复杂，除了活性物质外，还可能包括表面活性剂或润肤剂等辅助物质。为了客观评价消毒剂的药效，需要有意义的药效数据。因此，欧洲标准化委员会技术委员会216“化学消毒剂和防腐剂”工作组1(医疗领域)已经制定了药效测试标准。欧洲的分级方法将杀灭病毒的效果分成三个级别，并使用相应的标记测试病毒。就SARS-CoV-2而言，应使用已被证明对牛痘病毒具有活性的消毒剂，以确保有效的卫生程序来控制大流行。牛痘病毒是欧洲声称的“对包膜病毒有效”的标志病毒。
When facing an emerging virus outbreak such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a quick reaction time is key to control the spread. It takes time to develop antivirals and vaccines, and implement vaccination campaigns. Therefore, preventive measures such as rapid isolation of cases and identification and early quarantine of cases’ close contacts—as well as masks, physical distancing, hand hygiene, surface disinfection and air control—are crucial to reduce the risk of transmission. In this context, disinfectants and antiseptics with proven efficacy against the outbreak virus should be used. However, biocidal formulations are quite complex and may include auxiliary substances such as surfactants or emollients in addition to active substances. In order to evaluate disinfectants’ efficacy objectively, meaningful efficacy data are needed. Therefore, the European Committee for Standardisation technical committee 216 ‘Chemical disinfectants and antiseptics’ Working Group 1 (medical area) has developed standards for efficacy testing. The European tiered approach grades the virucidal efficacy in three levels, with corresponding marker test viruses. In the case of SARS-CoV-2, disinfectants with proven activity against vaccinia virus, the marker virus for the European claim ‘active against enveloped viruses’, should be used to ensure effective hygiene procedures to control the pandemic.