Double- and triple-cobalt catalysis in multicomponent reactions.
Double- and triple-cobalt catalysis in multicomponent reactions.
复制标题
DOI：
10.1021/ol300504f
复制
发表时间：
2012-03
期刊：
影响因子：
5.2
通讯作者：
Florian Erver;G. Hilt
中科院分区：
文献类型：
--
作者：
Florian Erver;G. Hilt
不同类型的钴催化转化在一锅程序的组合进行了描述。其中一个关键的结构单元，硼官能化的异戊二烯衍生物（boroprene），导致实现四组分反应序列，包括钴催化的狄尔斯-阿尔德和1，4-加氢乙烯化反应。最终，包括钴催化的Diels-Alder反应、钴催化的1，4-加氢乙烯基化、烯丙基硼酸化和钴催化的Alder-ene反应的反应序列导致五组分一锅反应序列，其中以优异的区域选择性和非对映选择性形成五个碳-碳键，以良好的总产率生成复杂产物。
The combination of different types of cobalt-catalyzed transformations in one-pot procedures is described. One of the key building blocks, a boron-functionalized isoprene derivative (boroprene), led to the realization of four-component reaction sequences comprising the cobalt-catalyzed Diels-Alder and a 1,4-hydrovinylation reaction. Eventually, a reaction sequence including a cobalt-catalyzed Diels-Alder reaction, a cobalt-catalyzed 1,4-hydrovinylation, an allylboration, and a cobalt-catalyzed Alder-ene reaction led to a five-component one-pot reaction sequence in which five carbon-carbon bonds were formed in excellent regio- and diastereoselectivity to generate complex products in good overall yields.