PREVALENCE OF RABIES SPECIFIC ANTIBODIES IN THE MEXICAN FREE-TAILED BAT (TADARIDA-BRASILIENSIS-MEXICANA) AT LAVA CAVE, NEW-MEXICO
PREVALENCE OF RABIES SPECIFIC ANTIBODIES IN THE MEXICAN FREE-TAILED BAT (TADARIDA-BRASILIENSIS-MEXICANA) AT LAVA CAVE, NEW-MEXICO
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DOI：
10.7589/0090-3558-25.4.490
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发表时间：
1989-10-01
影响因子：
1.3
通讯作者：
ALTENBACH, JS
中科院分区：
文献类型：
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作者：
STEECE, R;ALTENBACH, JS
成年女性和青少年墨西哥自由尾蝙蝠（Tadarida brasiliensis mexicana），每两个月收集在熔岩洞，新墨西哥州从5月至9月。本研究的目的是检查活动性狂犬病感染的患病率以及确定这些宿主的个体免疫状态。所有蝙蝠流血的，并利用改良的血清中和试验检查狂犬病抗体（总抗体与IgM）。取出脑，并通过荧光狂犬病抗体（FRA）试验进行检查。在研究期间，未观察到具有狂犬病中和抗体的成人数量（总数）存在显著差异。狂犬病中和抗体（总）之间的显着差异，观察到在7月和8月期间采样的青少年。成人IgM特异性抗体的数量很低（15 750，2%），并没有波动显着。然而，8月和9月，IgM抗体阳性的静脉人数确实有所增加。FRA阳性的成年人数量很低（750人中有4人，< 1%），在研究期间似乎没有明显波动。FRA阳性的青少年人数比成年人高出3.5倍（600人中有14人，2%）。这些结果表明，墨西哥无尾蝙蝠似乎暴露于狂犬病病毒出生后不久，其免疫状态明显。通过FRA和小鼠接种确定的活动性感染的低流行率（4/750，< 1%）和成年雌性中IgG抗体的高流行率（514/750，69%）表明墨西哥无尾蝙蝠从狂犬病病毒感染中恢复。
Adult female and juvenile Mexican free-tailed bats (Tadarida brasiliensis mexicana) were collected bimonthly at Lava Cave, New Mexico from May through September. The purpose of this study was to examine the prevalence of active rabies infection as well as to determine individual immune status in these hosts. All bats were bled and examined for rabies antibody (total antibody versus IgM) utilizing a modified serum neutralization test. The brains were removed and examined by the fluorescent rabies antibody (FRA) test. No significant difference was observed in the number of adults with rabies neutralizing antibody (total) over the study period. Significant differences in rabies neutralizing antibody (total) were observed among the juveniles sampled during July and August. The number of adults with IgM specific antibody was low (15 of 750, 2%) and did not fluctuate significantly. However, the number of veniles with IgM antibody did show increased levels in August and September. The number of adults positive by the FRA was low (4 of 750, < 1%) and did not appear to fluctuate significantly over the study period. The number of juveniles positive by the FRA was three and one-half times higher than observed for the adults (14 of 600, 2%). These results indicate that the Mexican free-tailed bat appears to be exposed to rabies virus shortly after birth as evident by its immune status. The low prevalence (4 of 750, < 1%) of active infection as determined by the FRA and mouse inoculation and the high prevalence (514 of 750, 69%) of IgG antibody in the adult females indicate that the Mexican free-tailed bat recovers from rabies virus infection.