Exposures, to diesel exhaust in the International Brotherhood of Teamsters, 1950-1990
Exposures, to diesel exhaust in the International Brotherhood of Teamsters, 1950-1990
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DOI：
10.1202/435.1
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发表时间：
2003-07-01
期刊：
影响因子：
--
通讯作者：
Steenland, K
中科院分区：
文献类型：
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作者：
Bailey, CR;Somers, JH;Steenland, K
先前的一项病例对照研究发现，在国际卡车司机兄弟会中部各州会议的死者中，暴露于柴油废气与肺癌之间存在正的、单调的因果关系。为了回应健康影响研究所柴油流行病学小组对卡车司机暴露估计的批评，本文调查了历史暴露和相关的不确定性。预测历史柴油机废气暴露是重型柴油卡车排放、柴油发动机使用增加以及20世纪80年代末和90年代初进行的职业元素碳（EC）测量的函数。柴油和非柴油来源的EC是根据最近的研究表明，汽油车的环境EC的重大贡献区分。蒙特卡罗抽样用于表征暴露分布。本文中使用的方法-历史暴露评估的概率模型-是新颖的。
A prior case-control study found a positive, monotonic exposure-response relationship between exposure to diesel exhaust and lung cancer among decedents of the Central States Conference of the International Brotherhood of Teamsters. In response to critiques of the Teamsters' exposure estimates by the Health Effects Institute's Diesel Epidemiology Panel, historical exposures and associated uncertainties are investigated here. Historic diesel exhaust exposures are predicted as a function of heavy-duty diesel truck emissions, increasing use of diesel engines, and occupational elemental carbon (EC) measurements taken during the late 1980s and early 1990s. EC from diesel and nondiesel sources is distinguished in light of recent studies indicating a substantial contribution of gasoline vehicles to ambient EC. Monte Carlo sampling is used to characterize exposure distributions. The methodology used in this article-a probabilistic model for historical exposure assessment-is novel.