Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus
Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus
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DOI：
10.1038/ncomms1026
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发表时间：
2010-06-01
影响因子：
16.6
通讯作者：
Garcia-Sastre, Adolfo
中科院分区：
文献类型：
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作者：
Medina, Rafael A.;Manicassamy, Balaji;Garcia-Sastre, Adolfo
1918年的甲型流感病毒造成了最具破坏性的大流行，全世界约有5000万人死亡。1918样和经典猪H1N1病毒疫苗免疫可产生针对2009年H1N1大流行性流感的交叉保护抗体，表明这些病毒之间的抗原相似性。在这项研究中，我们证明，接种2009年大流行性H1N1疫苗可在小鼠和人类中引发1918病毒交叉保护抗体，并且疫苗接种或人类阳性血清的被动转移可降低发病率，并使小鼠完全免受1918病毒的致命攻击。2009年H1N1流感病毒在全世界人口中的传播，除了大量已接种疫苗的个人之外，表明现在有很大一部分人口具有针对1918年病毒的交叉保护性抗体，大大减轻了对1918年病毒从实验室意外暴露/释放以及将该病毒用作生物恐怖主义剂的关切和恐惧。
The 1918 influenza A virus caused the most devastating pandemic, killing approximately 50 million people worldwide. Immunization with 1918-like and classical swine H1N1 virus vaccines results in cross-protective antibodies against the 2009 H1N1 pandemic influenza, indicating antigenic similarities among these viruses. In this study, we demonstrate that vaccination with the 2009 pandemic H1N1 vaccine elicits 1918 virus cross-protective antibodies in mice and humans, and that vaccination or passive transfer of human-positive sera reduced morbidity and conferred full protection from lethal challenge with the 1918 virus in mice. The spread of the 2009 H1N1 influenza virus in the population worldwide, in addition to the large number of individuals already vaccinated, suggests that a large proportion of the population now have cross-protective antibodies against the 1918 virus, greatly alleviating concerns and fears regarding the accidental exposure/release of the 1918 virus from the laboratory and the use of the virus as a bioterrorist agent.