cAMP response element binding protein phosphorylation in nucleus accumbens underlies sustained recovery of sensorimotor gating following repeated D₂-like receptor agonist treatment in rats.
cAMP response element binding protein phosphorylation in nucleus accumbens underlies sustained recovery of sensorimotor gating following repeated D₂-like receptor agonist treatment in rats.
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DOI：
10.1016/j.biopsych.2010.08.032
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发表时间：
2011-02-01
影响因子：
10.6
通讯作者：
Hammer, Ronald P., Jr.
中科院分区：
文献类型：
--
作者：
Berger, Alison K.;Green, Thomas;Siegel, Steven J.;Nestler, Eric J.;Hammer, Ronald P., Jr.
Prepulse inhibition (PPI) is a cross-species measure of sensorimotor gating. PPI deficits are observed in humans and rats upon acute treatment with dopamine D2-like receptor agonists, and in patients with schizophrenia. Repeated treatment with a D2-like agonist, however, reverses PPI deficits and increases cAMP signaling in the nucleus accumbens (NAc). The present study examined the short and long-term effects on PPI of treatment with quinpirole and ropinirole, dopamine D2/D3 receptor agonists, and the molecular mechanism by which they occur. PPI was assessed in adult male Sprague-Dawley rats following acute and chronic treatment with quinpirole or ropinirole, and 1, 2, 3, and 4 weeks after termination of repeated ropinirole treatment. Finally, the effect of dominant negative mutant CREB overexpression in the NAc on PPI following chronic quinpirole treatment was assessed. Acute quinpirole produced dose-dependent PPI deficits, while ropinirole caused consistent PPI reduction at all but the highest dose. Repeated ropinirole treatment significantly increased PPI compared to acute treatment, and increased CREB phosphorylation in NAc neurons. Subsequent ropinirole challenge had no effect as long as 28 days later, at which time NAc CREB phosphorylation had normalized. Overexpression of dominant negative mutant CREB prevented PPI recovery induced by chronic quinpirole treatment. Chronic quinpirole or ropinirole treatment produces sustained PPI recovery; CREB activity in the NAc is required to induce PPI recovery, but not to maintain it. The results suggest that transcriptional regulation by CREB mediates long-lasting changes occurring within NAc circuits to promote recovery of sensorimotor gating.
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影响因子：
5
作者：
Perachon, S;Schwartz, JC;Sokoloff, P
通讯作者：
Sokoloff, P
影响因子：
8.6
作者：
Hersh, Bonnie P.;Earl, Nancy L.;Stacy, Mark
通讯作者：
Stacy, Mark
影响因子：
4.7
作者：
OLIANAS, MC;ONALI, P
通讯作者：
ONALI, P
DOI：
10.1124/jpet.103.057158
发表时间：
2004-02-01
影响因子：
3.5
作者：
Culm, KE;Hammer, RP
通讯作者：
Hammer, RP
影响因子：
--
作者：
Sethi, KD;O'Brien, CF;Hauser, RA
通讯作者：
Hauser, RA