Longitudinal assessment of quality of life and lifestyle in newly diagnosed ovarian cancer patients: The roles of surgery and chemotherapy
Longitudinal assessment of quality of life and lifestyle in newly diagnosed ovarian cancer patients: The roles of surgery and chemotherapy
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DOI：
10.1016/j.ygyno.2006.01.059
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发表时间：
2006-10-01
影响因子：
4.7
通讯作者：
Gil, Karen M.
中科院分区：
文献类型：
--
作者：
von Gruenigen, Vivian E.;Frasure, Heidi E.;Gil, Karen M.
目标。目的前瞻性评估卵巢癌患者确诊后前6个月的生活质量(QOL)、补充和替代药物(CAM)的使用以及饮食/运动变化。新诊断的卵巢癌患者在手术前或手术后3个月和6个月进行调查。使用癌症治疗功能评估(FACT-G)、医疗结果调查(SF-36)和CAM/饮食/锻炼问卷。采用独立样本t检验和重复测量方差分析。42名患者在化疗前接受了手术去髓核和分期。与术前完成调查的患者相比，术后完成初始调查的患者的生理事实-G和SF-36身体评分显著降低。在完成术前基线调查的患者中，在3个月时(手术后和化疗期间)体格评分下降。与患者术后完成基线调查时相比，3个月时观察到的变化不大。与3个月相比，6个月时的身体和功能幸福感有所增加。随着时间的推移，情绪或社交得分没有变化。CAM使用量随时间增加；主要原因是为了改善生活质量和缓解症状。未发现饮食和运动方面的改变。这些数据强调了在手术前和手术后进行评估的必要性，以确定手术和/或化疗的影响。患者可能在化疗期间使用CAM来处理症状和补偿降低的生活质量。应该实施干预试验，以提高手术后和辅助化疗期间的生活质量。(C)2006 Elsevier Inc.保留所有权利。
Objectives. To prospectively evaluate quality of life (QoL), use of complementary and alternative medicine (CAM), and diet/exercise changes in ovarian cancer patients during the first 6 months following diagnosis.Methods. Patients with newly diagnosed ovarian cancer were enrolled pre- or post-operatively and surveyed at 3 and 6 months. The Functional Assessment of Cancer Therapy (FACT-G), Medical Outcomes Survey (SF-36), and CAM/diet/exercise questionnaires were used. Independent samples t test and repeated measures ANOVA were used.Results. Forty-two patients underwent surgical debulking and staging prior to chemotherapy. Patients completing the initial surveys post-operatively had significantly lower physical FACT-G and SF-36 physical scores compared to patients completing the surveys pre-operatively. In patients completing the baseline survey pre-operatively, there was a decrease in physical scores at 3 months (after surgery and during chemotherapy). There was no change observed at 3 months relative to baseline when patients completed the baseline survey post-operatively. Increases in physical and functional well-being were seen at 6 months relative to 3 months. There were no changes in emotional or social scores over time. CAM use increased over time; main reasons were to improve QoL and relieve symptoms. Alterations in diet and exercise were not seen.Conclusions. These data highlight the need to conduct assessments before and after surgery to identify effects due to surgery and/or chemotherapy. Patients may be using CAM during chemotherapy to deal with symptoms and compensate for decreased QoL. Intervention trials should be implemented to increase QoL following surgery and during adjuvant chemotherapy. (c) 2006 Elsevier Inc. All rights reserved.