Risk Factors Associated with Campylobacter jejuni Infections in Curaçao, Netherlands Antilles
Risk Factors Associated with Campylobacter jejuni Infections in Curaçao, Netherlands Antilles
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荷属安的列斯群岛库拉索岛空肠弯曲菌感染的相关危险因素
DOI：
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发表时间：
2003
影响因子：
9.4
通讯作者：
I. Gerstenbluth
中科院分区：
文献类型：
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作者：
H. Endtz;Hanneke M. van West;P. Godschalk;Lidewij de Haan;Y. Halabi;N. van den Braak;Barbara I Kesztyüs;Ewald Leyde;A. Ott;R. Verkooyen;Lawrence J. Price;D. Woodward;F. Rodgers;C. Ang;R. van Koningsveld;A. van Belkum;I. Gerstenbluth
据报道，荷兰安的列斯群岛库拉帕拉索的格林-巴罗综合征（GBS）发病率稳步上升，具有季节性优势，几乎完全与空肠弯曲杆菌有关，实验室证实的弯曲杆菌肠炎发病率也有所上升。因此，我们调查了与流行性空肠梭菌引起的腹泻相关的可能危险因素。脉冲场凝胶电泳分型鉴定出4个流行克隆，占感染病例的近60%。106例病例纳入病例对照研究。在库拉帕拉索州首府威廉斯塔德的特定地区，更经常观察到流行病克隆感染。其中一个克隆只在雨季引起感染，并且与房子周围有一口深井有关。3个与gbs相关的空肠梭菌分离株中有2个属于流行病克隆。观察结果表明，水可能是弯曲杆菌感染的来源。
ABSTRACT A steady increase in the incidence of Guillain-Barré syndrome (GBS) with a seasonal preponderance, almost exclusively related to Campylobacter jejuni, and a rise in the incidence of laboratory-confirmed Campylobacter enteritis have been reported from Curaçao, Netherlands Antilles. We therefore investigated possible risk factors associated with diarrhea due to epidemic C. jejuni. Typing by pulsed-field gel electrophoresis identified four epidemic clones which accounted for almost 60% of the infections. One hundred six cases were included in a case-control study. Infections with epidemic clones were more frequently observed in specific districts in Willemstad, the capital of Curaçao. One of these clones caused infections during the rainy season only and was associated with the presence of a deep well around the house. Two out of three GBS-related C. jejuni isolates belonged to an epidemic clone. The observations presented point toward water as a possible source of Campylobacter infections.