The development of neural synchrony reflects late maturation and restructuring of functional networks in humans
The development of neural synchrony reflects late maturation and restructuring of functional networks in humans
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DOI：
10.1073/pnas.0900390106
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发表时间：
2009-06-16
影响因子：
11.1
通讯作者：
Rodriguez, Eugenio
中科院分区：
文献类型：
--
作者：
Uhlhaas, Peter J.;Roux, Frederic;Rodriguez, Eugenio
大脑发育的特点是从儿童期到青春期再到成年期的成熟过程，但很少有人知道这些阶段的发育过程是否以及如何不同。我们通过测量68名年龄从6岁到21岁不等的参与者在完形知觉任务期间的EEG记录中的神经同步性来分析功能网络的发展。直到青春期早期，认知能力的发展改善伴随着神经同步性的增加。在这个发育阶段之后，在青春期后期发生了意想不到的神经同步性下降，并与表现下降有关。经过这段时间的不稳定，我们观察到的重组同步模式，伴随着显着的增加，在伽玛波段的功率和θ和β相位同步。这些发现为神经同步性和晚期大脑发育之间的关系提供了证据，这对理解青春期作为大脑成熟的关键时期具有重要意义。
Brain development is characterized by maturational processes that span the period from childhood through adolescence to adulthood, but little is known whether and how developmental processes differ during these phases. We analyzed the development of functional networks by measuring neural synchrony in EEG recordings during a Gestalt perception task in 68 participants ranging in age from 6 to 21 years. Until early adolescence, developmental improvements in cognitive performance were accompanied by increases in neural synchrony. This developmental phase was followed by an unexpected decrease in neural synchrony that occurred during late adolescence and was associated with reduced performance. After this period of destabilization, we observed a reorganization of synchronization patterns that was accompanied by pronounced increases in gamma-band power and in theta and beta phase synchrony. These findings provide evidence for the relationship between neural synchrony and late brain development that has important implications for the understanding of adolescence as a critical period of brain maturation.