Novel Urinary Biomarkers in Early Diabetic Kidney Disease
Novel Urinary Biomarkers in Early Diabetic Kidney Disease
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DOI：
10.1007/s11892-014-0513-1
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发表时间：
2014-08-01
影响因子：
4.2
通讯作者：
Kimura, Kenjiro
中科院分区：
文献类型：
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作者：
Kamijo-Ikemori, Atsuko;Sugaya, Takeshi;Kimura, Kenjiro
在糖尿病肾病中，尿白蛋白检测被推荐用于辅助诊断、评估疾病严重程度和确定治疗效果。然而，由于糖尿病肾病的典型组织病理学改变或正常白蛋白尿患者的早期进行性肾功能下降，尿白蛋白可能不足以识别早期糖尿病肾病患者或预测其进展。因此，人们一直在努力寻找新的非侵入性尿液生物标志物，以区分终末期肾功能衰竭风险较高的患者。由于糖尿病肾病的进展与肾小球组织学改变的程度和肾小管间质改变的程度有关，准确反映组织病理损害程度的尿生物标记物可能是很好的生物标记物。本文综述了新的尿液生物标志物在糖尿病肾病早期诊断中的临床意义。
In diabetic kidney disease, detection of urinary albumin is recommended to aid in diagnosis, evaluate disease severity, and determine effects of therapy. However, because typical histopathologic changes in diabetic kidney disease or early progressive renal decline may occur in patients with normoalbuminuria, urinary albumin may not be sufficient to identify patients with early-stage diabetic kidney disease or to predict its progression. Therefore, intensive efforts have been made to identify novel noninvasive urinary biomarkers to discriminate patients with a higher risk of end-stage renal failure. Because diabetic kidney disease progression is associated with the extent of histologic changes in the glomeruli and the degree of tubulointerstitial changes, urinary biomarkers that accurately reflect the degree of histopathologic damage may be excellent biomarkers. This review article summarizes the clinical significance of new urinary biomarkers in the early detection of diabetic kidney disease.