Association of Recent Bacterial Vaginosis With Acquisition of Mycoplasma genitalium
Association of Recent Bacterial Vaginosis With Acquisition of Mycoplasma genitalium
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DOI：
10.1093/aje/kwx043
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发表时间：
2017-07-15
影响因子：
5
通讯作者：
Manhart, Lisa E.
中科院分区：
文献类型：
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作者：
Lokken, Erica M.;Balkus, Jennifer E.;Manhart, Lisa E.
我们评估了近期细菌性阴道病（BV）与生殖支原体（一种与女性生殖健康不良结局相关的性传播细菌）事件之间的关系。肯尼亚蒙巴萨的女性性工作者完成了每月一次的性行为访谈和临床检查。在2005年2月至2006年2月期间，每隔一个月从妇女收集的阴道液标本进行了M。生殖器的核酸扩增检测。每月评估阴道微生物群，并通过Nugent评分进行分类（0-3 =正常微生物群，4-6 =中等微生物群破坏，7-10 = BV）。使用逻辑回归对多个事件进行离散失效时间分析，以估计事件M的几率。在前一次访视时患有BV（与正常微生物群相比）的女性中，在随访访视时生殖器感染。在280名妇女中，54.3%的人免疫缺陷病毒阳性。基线时，16.1%的患者存在M。生殖器感染率为40.4%，BV感染率为40.4%。有59个事件M。50名妇女生殖器感染，发病率为每100人年34.6例。在调整年龄、人类免疫缺陷病毒状态和时间后，既往BV与M事件的几率增加3.5倍相关。生殖器（校正比值比= 3.49，95%置信区间：1.86，6.56）。这种强相关性表明BV可能增强对M的易感性。生殖器感染
We assessed the association between recent bacterial vaginosis (BV) and incident Mycoplasma genitalium, a sexually transmitted bacterium associated with adverse female reproductive health outcomes. Female sex workers in Mombasa, Kenya, completed a monthly sexual behavior interview and clinical examination. During February 2005-February 2006, vaginal fluid specimens collected from women every other month were tested for M. genitalium by nucleic acid amplification testing. Vaginal microbiota were assessed monthly and categorized by Nugent score (0-3 = normal microbiota, 4-6 = intermediate microbiota disruption, and 7-10 = BV). A discrete failure time analysis for multiple events using logistic regression was employed to estimate the odds of incident M. genitalium infection at follow-up visits among women with BV (vs. normal microbiota) at the preceding visit. Among the 280 women, 54.3% were positive for human immunodeficiency virus. At baseline, 16.1% had prevalent M. genitalium infection and 40.4% had prevalent BV. There were 59 incident M. genitalium infections among 50 women, for an incidence rate of 34.6 cases per 100 person-years. Following adjustment for age, human immunodeficiency virus status, and time, prior BV was associated with a 3.5-fold increase in odds of incident M. genitalium (adjusted odds ratio = 3.49, 95% confidence interval: 1.86, 6.56). This strong association suggests that BV may enhance susceptibility to M. genitalium infection.