Fetal jaw movement affects condylar cartilage development
Fetal jaw movement affects condylar cartilage development
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DOI：
10.1177/154405910508400514
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发表时间：
2005-05-01
影响因子：
7.6
通讯作者：
Otani, H
中科院分区：
文献类型：
--
作者：
Habib, H;Hatta, T;Otani, H
使用小鼠子宫外系统来检查胎儿下颌运动对髁软骨发育的影响，我们评估了在胚胎日 (E)15.5 通过缝合限制动物张嘴的效果。我们假设产前颌运动是下颌髁突软骨内骨形成的重要机械因素。 E18.5缝合组髁软骨尺寸减小，骨软骨边缘界限不清。在E16.5和E18.5时，缝合组间质区的体积、细胞总数和5-溴-2'-脱氧尿苷阳性细胞数低于未缝合组。 E18.5时缝合组肥大软骨细胞较大，但肥大区软骨细胞和破骨细胞凋亡较少。我们的数据分析表明，胎儿颞下颌关节运动受限会影响髁软骨的软骨内骨形成过程。
Using a mouse exo utero system to examine the effects of fetal jaw movement on the development of condylar cartilage, we assessed the effects of restraint of the animals' mouths from opening, by suture, at embryonic day (E)15.5. We hypothesized that pre-natal jaw movement is an important mechanical factor in endochondral bone formation of the mandibular condyle. Condylar cartilage was reduced in size, and the bone-cartilage margin was ill-defined in the sutured group at E18.5. Volume, total number of cells, and number of 5-bromo-2'-deoxyuridine-positive cells in the mesenchymal zone were lower in the sutured group than in the non-sutured group at E16.5 and E18.5. Hypertrophic chondrocytes were larger, whereas fewer apoptotic chondrocytes and osteoclasts were observed in the hypertrophic zone in the sutured group at E18.5. Analysis of our data revealed that restricted fetal TMJ movement influences the process of endochondral bone formation of condylar cartilage.