Is Chronic Curcumin Supplementation Neuroprotective Against Ischemia for Antioxidant Activity, Neurological Deficit, or Neuronal Apoptosis in an Experimental Stroke Model?
Is Chronic Curcumin Supplementation Neuroprotective Against Ischemia for Antioxidant Activity, Neurological Deficit, or Neuronal Apoptosis in an Experimental Stroke Model?
复制标题
DOI：
10.5137/1019-5149.jtn.17405-16.0
复制
发表时间：
2017-07-01
影响因子：
0.8
通讯作者：
Gulcubuk, Ahmet
中科院分区：
文献类型：
--
作者：
Altinay, Serdar;Cabalar, Murat;Gulcubuk, Ahmet
目的：探讨慢性补充姜黄素对大鼠前脑缺血再灌流的保护作用。材料与方法：采用双侧颈总动脉结扎1/2小时后再灌流72小时的方法复制大鼠前脑缺血模型。老年大鼠分为5组：I组缺血前21天口服姜黄素300 mg/kg，缺血后腹腔注射300 mg/kg姜黄素；II组缺血后腹腔注射300 mg/kg姜黄素；III组缺血前21天口服300 mg/kg姜黄素；IV组单纯缺血；V组为假手术组。结果：I组大鼠前脑组织中超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性明显高于II组和III组(P<0.05)。
AIM: To investigate the neuroprotective effect of chronic curcumin supplementation on the rat forebrain prior to ischemia and reperfusion.MATERIAL and METHODS: Forebrain ischemia was induced by bilateral common carotid artery occlusion for 1/2 hour, followed by reperfusion for 72 hours. Older rats were divided into five groups: Group I received 300 mg/kg oral curcumin for 21 days before ischemia and 300 mg/kg intraperitoneal curcumin after ischemia; Group II received 300 mg/kg intraperitoneal curcumin after ischemia; Group III received 300 mg/kg oral curcumin for 21 days before ischemia; Group IV had only ischemia; Group V was the sham-operated group. The forebrain was rapidly dissected for biochemical parameter assessment and histopathological examination.RESULTS: In forebrain tissue, enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase were significantly higher in Group I than Groups II or III (p