DNA vaccine.
DNA vaccine.
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DOI：
10.1016/s0065-2660(05)54011-2
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发表时间：
2005
影响因子：
--
通讯作者：
Cui Z
中科院分区：
文献类型：
--
作者：
Cui Z
DNA疫苗已被证明是基因治疗领域最有前途的应用之一。由于其独特的容易诱导体液和细胞免疫反应的能力，当这个概念在 20 世纪 90 年代初首次得到证实时，它引起了极大的兴趣。在发表了数千篇与DNA疫苗相关的文章后，科学家们开始意识到，尽管DNA疫苗在小动物模型中非常有效，但其在最近的临床试验中的效果却相当令人失望。因此，目前的努力已转向了解 DNA 疫苗在小鼠和大型动物模型中的不同性能，以及如何将 DNA 疫苗在小动物中的成功转移到大型动物和人类身上。
The DNA vaccine has proven to be one of the most promising applications in the field of gene therapy. Due to its unique ability to readily induce humoral as well as cellular immune responses, it attracted great interest when the concept was first confirmed in the early 1990s. After thousands of articles related to the DNA vaccine were published, scientists began to realize that although the DNA vaccine is very effective in small animal models, its effectiveness in recent clinical trails is rather disappointing. Therefore, current effort has been shifted to understanding the different performance of the DNA vaccine in mouse and large animal models and on how to transfer the success of the DNA vaccine in small animals to large animals and humans.