High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis
High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis
复制标题
DOI：
10.1002/art.23187
复制
发表时间：
2008-01-01
影响因子：
--
通讯作者：
Kahan, A.
中科院分区：
文献类型：
--
作者：
Allanore, Y.;Avouac, J.;Kahan, A.
Objective.评估系统性硬化症（SSc）患者前瞻性队列中肺动脉高压（PAH）的预测因素。在101例无PAH或重度合并症的SSc患者的前瞻性队列中进行常规临床评估以及一氧化碳弥散量/肺泡容积（DLCO/VA）比值和N末端脑钠肽前体（NT-proBNP）水平的测量。在计划的36个月随访后，我们评价了这些参数对毛细血管前PAH发展的预测价值，如心导管插入术、疾病进展和死亡所示。心导管检查的标准是超声心动图显示收缩期肺动脉压（PAP）>40 mm Hg，DLco值为28 mm/h（P = 0.015）。在多变量分析中，基线NT-proBNP水平升高（风险比[HR] 9.97 [95%置信区间（95% CI）1.69-62.42]）和DLcoNA比值
Objective. To evaluate predictors of pulmonary arterial hypertension (PAH) in a prospective cohort of patients with systemic sclerosis (SSc).Methods. Routine clinical assessments as well as measurements of the diffusing capacity for carbon monoxide/alveolar volume (DLCO/VA) ratio and N-terminal pro-brain natriuretic peptide (NT-proBNP) level were performed in a prospective cohort of 101 SSc patients who did not have PAH or severe comorbidities. After a planned 36-month followup, we evaluated the predictive value of these parameters for the development of precapillary PAH, as demonstrated by cardiac catheterization, disease progression, and death. Criteria for cardiac catheterization were a systolic pulmonary artery pressure (PAP) of >40 mm Hg on echocardiography, a DLco value of 28 mm/hour (P = 0.015). In multivariate analyses, an elevated baseline NT-proBNP level (hazard ratio [HR] 9.97 [95% confidence interval (95% CI) 1.69-62.42]) and a DLcoNA ratio