The subthalamic region is activated during valence-related emotional processing in patients with Parkinson's disease
The subthalamic region is activated during valence-related emotional processing in patients with Parkinson's disease
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DOI：
10.1111/j.1460-9568.2007.05683.x
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发表时间：
2007-08-01
影响因子：
3.4
通讯作者：
Kuehn, A. A.
中科院分区：
文献类型：
--
作者：
Bruecke, C.;Kupsch, A.;Kuehn, A. A.
视觉刺激基于两个基本维度（效价和唤醒）来判断其情感意义，并可能导致神经和身体功能的变化，如注意力，情感，记忆力和心率。接受功能性神经外科手术的帕金森病（PD）患者出现了行为和情绪的变化，这表明对丘脑底核（STN）的高频电刺激可能会干扰情绪信息处理。在这里，我们利用这个机会，直接记录神经元活动从帕金森病患者的脑电宏电极在介绍情绪负荷和中性的图片从国际情感图片系统（IAPS），以进一步阐明的作用，脑电在情绪处理。我们发现一个显着的事件相关的deserminization的α活动与愉快的刺激，与个人的效价评级的图片。我们的研究结果表明，参与的人类大脑中的价相关的情绪信息处理，可以潜在地改变在高频刺激的帕金森氏症导致行为并发症。
Visual stimuli are judged for their emotional significance based on two fundamental dimensions, valence and arousal, and may lead to changes in neural and body functions like attention, affect, memory and heart rate. Alterations in behaviour and mood have been encountered in patients with Parkinson's disease (PD) undergoing functional neurosurgery, suggesting that electrical high-frequency stimulation of the subthalamic nucleus (STN) may interfere with emotional information processing. Here, we use the opportunity to directly record neuronal activity from the STN macroelectrodes in patients with PD during presentation of emotionally laden and neutral pictures taken from the International Affective Picture System (IAPS) to further elucidate the role of the STN in emotional processing. We found a significant event-related desynchronization of STN alpha activity with pleasant stimuli that correlated with the individual valence rating of the pictures. Our findings suggest involvement of the human STN in valence-related emotional information processing that can potentially be altered during high-frequency stimulation of the STN in PD leading to behavioural complications.