Accelerated aging studies of UHMWPE. I. Effect of resin, processing, and radiation environment on resistance to mechanical degradation.
Accelerated aging studies of UHMWPE. I. Effect of resin, processing, and radiation environment on resistance to mechanical degradation.
复制标题
UHMWPE 的加速老化研究。
DOI：
10.1002/jbm.10135
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
S. Kurtz
中科院分区：
文献类型：
--
作者：
A. Edidin;M. Herr;M. Villarraga;J. Muth;S. Yau;S. Kurtz
树脂和加工路线已被确定为影响超高相对分子质量聚乙烯(UHMWPE)整形外科部件的机械性能和临床性能的潜在变量。研究人员报告称，在空气中伽马灭菌后的货架老化过程中，由1900树脂制成的组件可能会比由GUR树脂制成的组件氧化程度较小。关于1900年的抗氧化性的相互矛盾的报告提出了一个问题，即树脂或制造方法，或者树脂和制造方法之间的相互作用，是否会影响UHMWPE的力学行为。我们进行了一系列加速老化研究(无老化、在氧气或氮气中老化)，系统地考察了树脂(GUR或1900)、制造方法(整体压缩成型或挤出)和灭菌方法(无、在空气中或在氮气中)对UHMWPE力学行为的影响。用小冲头测试技术评价了材料的力学行为，并用傅里叶变换红外光谱表征了选定样品的氧化情况。我们的研究表明，灭菌环境、老化条件和样品位置(表面或亚表面)对UHMWPE的力学行为有显著影响。在氧气中的人工老化和空气中的伽马辐射后，被评估的三种聚乙烯中的每一种似乎都按照类似的途径降解。材料最初表现出屈服后应变硬化的能力因降解而显著降低。总体而言，模压和挤压GUR 1050的老化行为只有很小的差异，而模压1900材料的降解似乎比1050材料中的任何一种略快。
The resin and processing route have been identified as potential variables influencing the mechanical behavior, and hence the clinical performance, of ultra-high molecular weight polyethylene (UHMWPE) orthopedic components. Researchers have reported that components fabricated from 1900 resin may oxidize to a lesser extent than components fabricated from GUR resin during shelf aging after gamma sterilization in air. Conflicting reports on the oxidation resistance for 1900 raise the question of whether resin or manufacturing method, or an interaction between resin and manufacturing method, influences the mechanical behavior of UHMWPE. We conducted a series of accelerated aging studies (no aging, aging in oxygen or in nitrogen) to systematically examine the influence of resin (GUR or 1900), manufacturing method (bulk compression molding or extrusion), and sterilization method (none, in air, or in nitrogen) on the mechanical behavior of UHMWPE. The small punch testing technique was used to evaluate the mechanical behavior of the materials, and Fourier transform infrared spectroscopy was used to characterize the oxidation in selected samples. Our study showed that the sterilization environment, aging condition, and specimen location (surface or subsurface) significantly affected the mechanical behavior of UHMWPE. Each of the three polyethylenes evaluated seem to degrade according to a similar pathway after artificial aging in oxygen and gamma irradiation in air. The initial ability of the materials to exhibit post-yield strain hardening was significantly compromised by degradation. In general, there were only minor differences in the aging behavior of molded and extruded GUR 1050, whereas the molded 1900 material seemed to degrade slightly faster than either of the 1050 materials.